Methyl 2,4-dibromobenzoate

Base Information

• Chemical Name: Methyl 2,4-dibromobenzoate
• CAS No.: 54335-33-0
• Molecular Formula: C8H6Br2O2
• Molecular Weight: 293.942
• Hs Code.: 2916399090
• Mol file: 54335-33-0.mol

Synonyms:Benzoic acid, 2,4-dibromo-, methyl ester;

Chemical Property of Methyl 2,4-dibromobenzoate

Chemical Property:

• Boiling Point: 307.981 °C at 760 mmHg
• Flash Point: 140.062 °C
• PSA: 26.30000
• Density: 1.841 g/cm³
• LogP: 2.99820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-DibromobenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dibromobenzoic Acid Methyl Ester is sued in the preparation of compounds with immunosuppressive inhibitory activity and antitumor activity. 2,4-Dibromobenzoic Acid Methyl Ester is used in the preparation of compounds with immunosuppressive inhibitory activity and antitumor activity.

Technology Process of Methyl 2,4-dibromobenzoate

There total 4 articles about Methyl 2,4-dibromobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2,4-dibromobenzoic acid (611-00-7) → methyl 2,4-dibromobenzoate (54335-33-0)

Guidance literature:

With thionyl chloride; at 0 ℃; for 3h; Reflux;

Reference yield:

2,4-dibromobenzoic acid (611-00-7) → methyl 2,4-dibromobenzoate (54335-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅

With phosphorus pentachloride;

Reference yield:

2,4-dibromobenzonitrile (78222-69-2) → methyl 2,4-dibromobenzoate (54335-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 120 - 130 °C / man behandelt das Amid in schwefelsaurer Loesung mit NaNO₂

2: PCl₅

With phosphorus pentachloride; sulfuric acid;

upstream raw materials:

methanol

2,4-dibromobenzoyl chloride

2,4-dibromobenzoic acid

2,4-dibromobenzonitrile

Downstream raw materials:

4-methoxycarbonylphenyl bromide

Refernces

• 1、 Bi, Lei,Fu, Chenchao,Yao, Lei. "Facile preparation of 6-(Aminomethyl)isoindolin-1-one realizing complete reduction of double aromatic cyano groups". . p. 6655 - 6657. Retrieved 2014.
• 2、 -. "IMMUNE ADJUSTMENT COMPOUND, USE THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME". Paragraph 0077; 0078. . Retrieved 2016/08/29.