7,10-Dimethoxy-10-DAB III

Base Information

Chemical Name:7,10-Dimethoxy-10-DAB III
CAS No.:183133-94-0
Molecular Formula:C31H40O10
Molecular Weight:572.653
Hs Code.:29329990
DSSTox Substance ID:DTXSID301098192
Mol file:183133-94-0.mol

Synonyms:7,10-Dimethoxy-10-DAB III;183133-94-0;(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one;[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,15-dihydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate;Cabazitaxel Impurity;10-Deacetyl-7,10-dimethylbaccatin III;7,10-Dimethoxy-10-deacetylbaccatin III;SCHEMBL7509209;7,10-Dimethoxy-10-DABIII;DTXSID301098192;BCP06123;EX-A3599;MFCD23100710;AKOS025401902;AC-27007;DS-12027;CS-0022604;F12858;A880845

Suppliers and Price of 7,10-Dimethoxy-10-DAB III

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
10-Deacetyl-7,10-dimethoxy-Baccatin III
50mg
$ 460.00

TRC
10-Deacetyl-7,10-dimethoxy-BaccatinIII
100mg
$ 355.00

Crysdot
7,10-Dimethoxy-10-DABIII 95+%
5g
$ 1485.00

Crysdot
7,10-Dimethoxy-10-DABIII 95+%
1g
$ 495.00

Chemenu
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-ylbenzoate 95%
1g
$ 468.00

Chemenu
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-ylbenzoate 95%
5g
$ 1403.00

Biosynth Carbosynth
7,10-Dimethoxy-10-DAB III)
1 g
$ 1200.00

Biosynth Carbosynth
7,10-Dimethoxy-10-DAB III)
2 g
$ 840.00

Biosynth Carbosynth
7,10-Dimethoxy-10-DAB III)
500 mg
$ 800.00

Biosynth Carbosynth
7,10-Dimethoxy-10-DAB III)
100 mg
$ 300.00

Total 104 raw suppliers

Chemical Property of 7,10-Dimethoxy-10-DAB III

Chemical Property:

Boiling Point:675.8±55.0 °C(Predicted)
PKA:12.82±0.70(Predicted)
PSA：137.82000
Density:1.31
LogP:2.39000
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:DMF (Slightly, Heated, Sonicated), DMSO (Very Slightly, Heated), Methanol and Wa
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:572.26214747
Heavy Atom Count:41
Complexity:1120

Purity/Quality:

99%, ^*data from raw suppliers

10-Deacetyl-7,10-dimethoxy-Baccatin III ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)OC)C)OC
Isomeric SMILES:CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)OC)C)OC
Description Cabazitaxel is a kind of Second line Drug for the treatment of prostate cancer, FDA Priority Review status approval listing is obtained because its curative effect is remarkable, for the advanced prostate cancer patients to the invalid even aggravation of Docetaxel, the first-selected medicine being used for the treatment of late period, hormone antagonist type prostate cancer.7,10-dimethoxy-10-Dab III is the important intermediate preparing Cabazitaxel.
Uses 4-Deacetyl-4-propionyl Cabazitaxel is an impurity of Cabazitaxel (C046500).A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.

Technology Process of 7,10-Dimethoxy-10-DAB III

There total 27 articles about 7,10-Dimethoxy-10-DAB III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 616-38-6
carbonic acid dimethyl ester

: 183133-94-0
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene

Guidance literature:: With dmap; caesium bromide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at -30 ℃; for 3h; Temperature; Reagent/catalyst;

Reference yield: 87.0%

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 333-27-7
methyl trifluoromethanesulfonate

: 183133-94-0
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene

Guidance literature:: 10-deacetylbaccatin III; With lithium hexamethyldisilazane; In tetrahydrofuran; at -72 ℃; for 0.666667h; Inert atmosphere;

methyl trifluoromethanesulfonate; In tetrahydrofuran; at -72 ℃; for 4.08333h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.11.037