2-(3-aminophenyl)-N-methylacetamide(SALTDATA: FREE)

Base Information

• Chemical Name: 2-(3-aminophenyl)-N-methylacetamide(SALTDATA: FREE)
• CAS No.: 58730-35-1
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Hs Code.: 2924299090
• Mol file: 58730-35-1.mol

Synonyms:2-(3-aminophenyl)-N-methylacetamide(SALTDATA: FREE);2-(3-AMinophenyl)-N-MethylacetaMide

Chemical Property of 2-(3-aminophenyl)-N-methylacetamide(SALTDATA: FREE)

Chemical Property:

• Boiling Point: 416.4±28.0 °C(Predicted)
• PKA: 16.00±0.46(Predicted)
• PSA: 58.61000
• Density: 1.117±0.06 g/cm3(Predicted)
• LogP: 1.97880

Purity/Quality:

98%min ^*data from raw suppliers

2-(3-aminophenyl)-N-methylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-aminophenyl)-N-methylacetamide(SALTDATA: FREE)

There total 6 articles about 2-(3-aminophenyl)-N-methylacetamide(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3-amino-phenyl)-acetic acid methyl ester (52913-11-8) + methylamine (74-89-5) → 2-(3-aminophenyl)-N-methylacetamide (58730-35-1)

Guidance literature:

In water; at 20 ℃; for 24h;

DOI:10.1039/d0md00074d

Reference yield: 70.0%

3-amino phenylacetic acid (14338-36-4) + methylamine (74-89-5) → 2-(3-aminophenyl)-N-methylacetamide (58730-35-1)

Guidance literature:

With benzotriazol-1-ol; diisopropyl-carbodiimide; In methanol; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

N-methyl-2-(3-nitrophenyl)acetamide (19281-10-8) → 2-(3-aminophenyl)-N-methylacetamide (58730-35-1)

Guidance literature:

With hydrogen; nickel; In ethanol; at 50 - 60 ℃; under 30002.4 - 37503 Torr;

upstream raw materials:

N-methyl-2-(3-nitrophenyl)acetamide

(3-nitrophenyl)acetyl chloride

3-amino phenylacetic acid

methylamine

Downstream raw materials:

2-[3-(3,3-Dimethyl-ureido)-phenyl]-N-methyl-acetamide

3-(N'-methylureido)-phenylacetic acid methylamide

Refernces

• 1、 -. "Aniline pyrimidines, its preparation method and medical use (by machine translation)". Paragraph 0130; 0219; 0220; 0221. . Retrieved 2018/03/01.