6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE

Base Information

• Chemical Name: 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE
• CAS No.: 778574-06-4
• Molecular Formula: C14H13Cl2N3
• Molecular Weight: 294.183
• Hs Code.: 29335990
• Mol file: 778574-06-4.mol

Synonyms:6-benzyl-2,4-dichloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine

Chemical Property of 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE

Chemical Property:

• Refractive Index: 1.584
• Boiling Point: 423.9 °C at 760 mmHg
• PKA: 4.42±0.20(Predicted)
• Flash Point: 210.2 °C
• PSA: 29.02000
• Density: 1.362 g/cm³
• LogP: 3.27960

Purity/Quality:

97% ^*data from raw suppliers

6-Benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE

There total 8 articles about 6-BENZYL-2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione (135481-57-1) → 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine (778574-06-4)

Guidance literature:

With trichlorophosphate; for 3h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2014.03.061

Reference yield: 79.0%

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diol → 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine (778574-06-4)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine (778574-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / ethanol / 24 h / Reflux

2: trichlorophosphate / 3 h / Inert atmosphere; Reflux

With sodium methylate; trichlorophosphate; In ethanol;

DOI:10.1016/j.ejmech.2014.03.061

upstream raw materials:

5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester

C₉H₁₄O₃NC₆H₅

benzylamine

Downstream raw materials:

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

C₂₀H₁₉ClN₄O₂S

C₂₁H₂₁ClN₄O₂S