5-bromo-3-chloro-2-isopropoxypyridine

Base Information

• Chemical Name: 5-bromo-3-chloro-2-isopropoxypyridine
• CAS No.: 1211531-67-7
• Molecular Formula: C₈H₉BrClNO
• Molecular Weight: 250.523
• Hs Code.: 2933399090
• Mol file: 1211531-67-7.mol

Synonyms:5-bromo-3-chloro-2-isopropoxypyridine

Chemical Property of 5-bromo-3-chloro-2-isopropoxypyridine

Chemical Property:

• Boiling Point: 249.5±35.0 °C(Predicted)
• PKA: -0.42±0.32(Predicted)
• PSA: 22.12000
• Density: 1.489±0.06 g/cm3(Predicted)
• LogP: 3.28470
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-3-chloro-2-isopropoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-3-chloro-2-isopropoxypyridine

There total 3 articles about 5-bromo-3-chloro-2-isopropoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-Isopropoxy-3-chloropyridine (282723-22-2) → 5-bromo-3-chloro-2-isopropoxypyridine (1211531-67-7)

Guidance literature:

With bromine; sodium acetate; In ethyl acetate; at 7 - 25 ℃;

Reference yield: 58.0%

5-bromo-2,3-dichloropyridine (97966-00-2) + isopropyl alcohol (67-63-0,8013-70-5) → 5-bromo-3-chloro-2-isopropoxypyridine (1211531-67-7)

Guidance literature:

isopropyl alcohol; With potassium tert-butylate; at 95 ℃; for 3h;

5-bromo-2,3-dichloropyridine; Reflux;

Reference yield:

2,3-dichloro-pyridine (2402-77-9) → 5-bromo-3-chloro-2-isopropoxypyridine (1211531-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 60 °C

2.1: sodium acetate; bromine / ethyl acetate / 7 - 25 °C

With bromine; sodium acetate; sodium hydride; In tetrahydrofuran; ethyl acetate;

upstream raw materials:

5-bromo-2,3-dichloropyridine

isopropyl alcohol

2,3-dichloro-pyridine

2-Isopropoxy-3-chloropyridine

Downstream raw materials:

3-chloro-5-(3-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazol-5-yl)-2-[(1-methylethyl)oxy]pyridine

[3-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]acetaldehyde

ethyl 1-{2-[3-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-thiadiazol-3-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

5-chloro-6-(1-propan-2-yloxy)-3-pyridinol