Methyl 5-chloro-2-methoxynicotinate

Base Information

• Chemical Name: Methyl 5-chloro-2-methoxynicotinate
• CAS No.: 82060-51-3
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.609
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40534571
• Wikidata: Q72489271
• Mol file: 82060-51-3.mol

Synonyms:methyl 5-chloro-2-methoxynicotinate;82060-51-3;methyl 5-chloro-2-methoxypyridine-3-carboxylate;METHYL 5-CHLORO-2-METHOXY-3-PYRIDINECARBOXYLATE;METHYL5-CHLORO-2-METHOXYNICOTINATE;SCHEMBL10473574;DTXSID40534571;KHGQMIBDLPEOCL-UHFFFAOYSA-N;3-Pyridinecarboxylic acid, 5-chloro-2-methoxy-, methyl ester;CL4540;MFCD12025883;AKOS005072039;AB65269;CD-0700;AC-23264;CS-0195104;A864464;Methyl 5-Chloro-2-methoxypyridine-3- carboxylate;J-522471

Chemical Property of Methyl 5-chloro-2-methoxynicotinate

Chemical Property:

• Boiling Point: 261℃
• Flash Point: 111℃
• PSA: 48.42000
• Density: 1.288
• LogP: 1.53020
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 201.0192708
• Heavy Atom Count: 13
• Complexity: 188

Purity/Quality:

97% ^*data from raw suppliers

Methyl 5-chloro-2-methoxynicotinate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=N1)Cl)C(=O)OC

Technology Process of Methyl 5-chloro-2-methoxynicotinate

There total 3 articles about Methyl 5-chloro-2-methoxynicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxynicotinic acid (16498-81-0) → methyl 5-Chloro-2-methoxypyridine-3-carboxylate (82060-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaOCl (Clorox) / Ambient temperature

2: concd. H₂SO₄ / 3 h / Heating

With sodium hypochlorite; sulfuric acid;

DOI:10.1021/jm00169a005

Reference yield:

methanol (67-56-1) + 5-chloro-2-methoxypyridine-3-carboxylic acid (54916-65-3) → methyl 5-Chloro-2-methoxypyridine-3-carboxylate (82060-51-3)

Guidance literature:

With sulfuric acid; for 3h; Yield given; Heating;

DOI:10.1021/jm00169a005

Reference yield:

→ methyl 5-Chloro-2-methoxypyridine-3-carboxylate (82060-51-3)

Guidance literature:

upstream raw materials:

methanol

5-chloro-2-methoxypyridine-3-carboxylic acid

2-methoxynicotinic acid