5-Methoxy-1,4-dihydronaphthalene

Base Information

• Chemical Name: 5-Methoxy-1,4-dihydronaphthalene
• CAS No.: 36230-47-4
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID10568707
• Nikkaji Number: J1.725.812E
• Wikidata: Q82455036
• Mol file: 36230-47-4.mol

Synonyms:5-methoxy-1,4-dihydronaphthalene;36230-47-4;1,4-dihydro-5-methoxynaphthalene;SCHEMBL506157;DTXSID10568707;TQP0334;ZKMHLJCHQKQLEE-UHFFFAOYSA-N

Chemical Property of 5-Methoxy-1,4-dihydronaphthalene

Chemical Property:

• PSA: 9.23000
• LogP: 2.35000
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 160.088815002
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

99% ^*data from raw suppliers

5-Methoxy-1,4-dihydronaphthalene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1CC=CC2

Technology Process of 5-Methoxy-1,4-dihydronaphthalene

There total 7 articles about 5-Methoxy-1,4-dihydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

5,8-dihydro-1-naphthol (27673-48-9) + dimethyl sulfate (77-78-1) → 1,4-dihydro-5-methoxynaphthalene (36230-47-4) + 5-methoxy-1,2,3,4-tetrahydro-naphthalene (1008-19-1)

Guidance literature:

5,8-dihydro-1-naphthol; With potassium carbonate; In ethanol;

dimethyl sulfate; In ethanol; at 0 - 40 ℃; for 2h;

Reference yield: 92.5%

5,8-dihydro-1-naphthol (27673-48-9) + dimethyl sulfate (77-78-1) → 1,4-dihydro-5-methoxynaphthalene (36230-47-4)

Guidance literature:

With potassium carbonate; In ethanol; at 0 - 40 ℃; for 2h;

Reference yield: 38.0%

1-Methoxynaphthalene (2216-69-5) → 1,4-dihydro-5-methoxynaphthalene (36230-47-4) + 5-methoxy-1,2,3,4-tetrahydro-naphthalene (1008-19-1)

Guidance literature:

With sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 3h; UV-irradiation;

DOI:10.1016/j.tetlet.2008.03.123

upstream raw materials:

5,8-dihydro-1-naphthol

dimethyl sulfate

1,5-dimethoxynaphthalene

α-naphthol

Downstream raw materials:

2,3-bis-(2-hydroxyethyl)-1-methoxybenzene

toluene-4-sulfonic acid (2R,4aR,10aR)-9-methoxy-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naptho[2,3-b][1,4]oxazin-2-ylmethyl ester

(2S,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine

(2R,4aR,10aR)-9-methoxy-2-(3-phenyl-pyrazol-1-ylmethyl)-4-propyl-3,4,4a,5,10,10a-hexahydro-2H-naphtho[2,3-b][1,4]oxazine