Technology Process of 3-hydroxy-1,5-naphthyridine-4-carbaldehyde
There total 11 articles about 3-hydroxy-1,5-naphthyridine-4-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium chloride;
In
N,N-dimethyl-formamide;
for 20h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -25 °C / Large scale reaction
2.2: 1 h / -70 - -65 °C
3.1: hydrogenchloride / methanol; water / 4 h / 45 °C / Large scale reaction
4.1: ferrous(II) sulfate heptahydrate; sodium 3-nitrobenzene sulfonate; sulfuric acid; boric acid / water / 6 h / 135 - 145 °C / Large scale reaction
5.1: lithium hydroxide / N,N-dimethyl-formamide / 24 h / 120 - 130 °C / Large scale reaction
6.1: sodium periodate / methanol; water / 16 h / 30 - 40 °C / Large scale reaction
7.1: lithium chloride / N,N-dimethyl-formamide / 0.5 h / 110 - 120 °C / Large scale reaction
With
hydrogenchloride; ferrous(II) sulfate heptahydrate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium periodate; n-butyllithium; sulfuric acid; sodium 3-nitrobenzene sulfonate; boric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
4.1: Skraup reaction;
DOI:10.1021/op300064b
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide / N,N-dimethyl-formamide / 24 h / 120 - 130 °C / Large scale reaction
2: sodium periodate / methanol; water / 16 h / 30 - 40 °C / Large scale reaction
3: lithium chloride / N,N-dimethyl-formamide / 0.5 h / 110 - 120 °C / Large scale reaction
With
sodium periodate; lithium chloride; lithium hydroxide;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/op300064b
