Technology Process of 5-Methoxy-4-methylpyridin-3-amine hydrochloride
There total 4 articles about 5-Methoxy-4-methylpyridin-3-amine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; methanol; water;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jm900729s
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 100 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -25 °C / Large scale reaction
2.2: 1 h / -70 - -65 °C
3.1: hydrogenchloride / methanol; water / 4 h / 45 °C / Large scale reaction
With
hydrogenchloride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; n-butyllithium; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/op300064b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran
2.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -25 °C / Large scale reaction
2.2: 1 h / -70 - -65 °C
3.1: hydrogenchloride / methanol; water / 4 h / 45 °C / Large scale reaction
With
hydrogenchloride; n-butyllithium;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/op300064b
