1056877-13-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxy-[1,5]naphthyridine-4-carbaldehyde is used as a key intermediate in the synthesis of various drugs and biologically active molecules. Its unique structure and functional groups make it a valuable component in the development of novel therapeutic agents.
Used in Drug Discovery:
3-Methoxy-[1,5]naphthyridine-4-carbaldehyde is used as a starting material for the development of new therapeutic agents. Its potential biological activities, such as anti-inflammatory and antiviral properties, make it a promising candidate for further research and development in the field of drug discovery.
Used in Anti-inflammatory Applications:
3-Methoxy-[1,5]naphthyridine-4-carbaldehyde is used as an anti-inflammatory agent due to its potential to modulate inflammatory pathways and alleviate inflammation-related symptoms. Its presence in various drug formulations can contribute to the management and treatment of inflammatory conditions.
Used in Antiviral Applications:
3-Methoxy-[1,5]naphthyridine-4-carbaldehyde is used as an antiviral agent, exhibiting potential to inhibit viral replication and reduce the severity of viral infections. Its antiviral properties make it a valuable component in the development of new antiviral drugs and therapies.

Upstream product

• 1056877-12-3 [(E)-2-(3-methoxy-[1,5]-naphthyridin-4-yl)-vinyl]-dimethyl-amine 
• 342603-10-5 tert-butyl 5-methoxypyridin-3-ylcarbamate 
• 64436-92-6 3-amino-5-methoxypyridine 
• 893566-34-2 (3-methoxy[1,5]naphthyridin-4-yl)methyl bromide 
• 893566-31-9 3-methoxy-4-methyl[1,5]naphthyridine 
• 1185094-00-1 3-amino-5-methoxy-4-methylpyridine hydrochloride 
• 1045858-10-3 tert-butyl 5-methoxy-4-methylpyridin-3-ylcarbamate 
• 50720-12-2 3-bromo-5-methoxypyridine 
• 1192255-92-7 (3-methoxy[1,5]naphthyridin-4-yl)methanol 

Downstream Products

• 1056877-14-5 3-hydroxy[1,5]naphthyridine-4-carbaldehyde 
• 1192256-10-2 3-descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,11-(oxycarbonyl-(1-((3-hydroxy-[1,5]naphthyridin-4-yl)-methyl)-azetidin-3-yl)-imino)-erythromycin A tosylate 

Relevant academic research and scientific papers

Process development of a novel azetidinyl ketolide antibiotic

Process development and the multikilogram synthesis of a novel azetidinyl ketolide antibiotic is described. Starting with clarithromycin, the eight-step synthesis features several telescoped operations and direct isolations, which results in a significant improvement in throughput and a major reduction in solvent usage and waste stream volume over the first scale-up campaign. Particular highlights of this effort include the development of an efficient synthesis of 3-hydroxy-1,5-naphthyridine-4-carbaldehyde via a Skraup process and engineering a robust final API synthesis. We also discovered a crystalline monotosylate salt that addressed significant formulation and degradation issues experienced when using the noncrystalline freebase.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections

Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safe