4-broMo-2-(2,6-dichlorophenyl)-7-fluoro-1H-iMidazo[4,5-c]pyridine

Base Information

• Chemical Name: 4-broMo-2-(2,6-dichlorophenyl)-7-fluoro-1H-iMidazo[4,5-c]pyridine
• CAS No.: 1334411-83-4
• Molecular Formula: C12H5BrCl2FN3
• Molecular Weight: 361
• Hs Code.: 2933990090
• Mol file: 1334411-83-4.mol

Synonyms:4-broMo-2-(2,6-dichlorophenyl)-7-fluoro-1H-iMidazo[4,5-c]pyridine

Chemical Property of 4-broMo-2-(2,6-dichlorophenyl)-7-fluoro-1H-iMidazo[4,5-c]pyridine

Chemical Property:

• Boiling Point: 519.9±60.0 °C(Predicted)
• PKA: 6.45±0.40(Predicted)
• PSA: 41.57000
• Density: 1.824±0.06 g/cm3(Predicted)
• LogP: 4.83330
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-broMo-2-(2,6-dichlorophenyl)-7-fluoro-1H-iMidazo[4,5-c]pyridine

There total 7 articles about 4-broMo-2-(2,6-dichlorophenyl)-7-fluoro-1H-iMidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-chloro-7-fluoro-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine (1334411-84-5) → 4-bromo-2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridine (1334411-83-4)

Guidance literature:

4-chloro-7-fluoro-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine; With trimethylsilyl bromide; In propiononitrile; at 120 ℃; for 12h;

With potassium carbonate; In water; propiononitrile; at 23 ℃; Cooling with ice;

Reference yield:

2-chloro-5-fluoro-4-nitropyridine-1-oxide (405230-80-0) → 4-bromo-2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridine (1334411-83-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen / Raney nickel / ethanol / 3 h / 2068.65 Torr

2.1: potassium nitrate; sulfuric acid / 1.17 h / 0 - 20 °C

2.2: 12 h / 20 °C

2.3: 5 °C / Cooling with ice

3.1: hydrogen / Raney nickel / ethanol / 2 h / 1861.78 Torr

4.1: oxygen; iron(III) chloride / 1,4-dioxane; ethanol / 10 h / 75 °C

4.2: Cooling with ice

5.1: trimethylsilyl bromide / propiononitrile / 12 h / 120 °C

5.2: 23 °C / Cooling with ice

With iron(III) chloride; trimethylsilyl bromide; sulfuric acid; hydrogen; oxygen; potassium nitrate; Raney nickel; In 1,4-dioxane; ethanol; propiononitrile;

Reference yield:

2-chloro-5-fluoropyridine (31301-51-6) → 4-bromo-2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridine (1334411-83-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: trifluoroacetic acid; dihydrogen peroxide / water / 70 - 75 °C

2.1: potassium nitrate; sulfuric acid / 2 h / 120 °C

2.2: 15 °C / Cooling with ice

3.1: hydrogen / Raney nickel / ethanol / 3 h / 2068.65 Torr

4.1: potassium nitrate; sulfuric acid / 1.17 h / 0 - 20 °C

4.2: 12 h / 20 °C

4.3: 5 °C / Cooling with ice

5.1: hydrogen / Raney nickel / ethanol / 2 h / 1861.78 Torr

6.1: oxygen; iron(III) chloride / 1,4-dioxane; ethanol / 10 h / 75 °C

6.2: Cooling with ice

7.1: trimethylsilyl bromide / propiononitrile / 12 h / 120 °C

7.2: 23 °C / Cooling with ice

With iron(III) chloride; trimethylsilyl bromide; sulfuric acid; hydrogen; dihydrogen peroxide; oxygen; potassium nitrate; trifluoroacetic acid; Raney nickel; In 1,4-dioxane; ethanol; water; propiononitrile;

upstream raw materials:

2-chloro-5-fluoropyridine

2-chloro-5-fluoropyridine-1-oxide

2-chloro-5-fluoro-4-nitropyridine-1-oxide

4-amino-2-chloro-5-fluoropyridine

Downstream raw materials:

2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

N-(2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-yl)cyclopropanecarboxamide

Refernces