4-amino-2-chloro-5-fluoropyridine

Base Information

Chemical Name:4-amino-2-chloro-5-fluoropyridine
CAS No.:89510-90-7
Molecular Formula:C5H4ClFN2
Molecular Weight:146.552
Hs Code.:2933399090
Mol file:89510-90-7.mol

Synonyms:2-chloro-5-fluoropyridin-4-amine

Suppliers and Price of 4-amino-2-chloro-5-fluoropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-chloro-5-fluoropyridin-4-amine
50mg
$ 45.00

SynQuest Laboratories
4-Amino-2-chloro-5-fluoropyridine
1 g
$ 288.00

Matrix Scientific
4-Amino-2-chloro-5-fluoropyridine 97%
5g
$ 780.00

Matrix Scientific
4-Amino-2-chloro-5-fluoropyridine 97%
500mg
$ 140.00

Matrix Scientific
4-Amino-2-chloro-5-fluoropyridine 97%
1g
$ 240.00

Crysdot
2-Chloro-5-fluoro-4-pyridinamine 97%
5g
$ 470.00

Chemenu
2-chloro-5-fluoropyridin-4-amine 97%
1g
$ 299.00

Atlantic Research Chemicals
2-Chloro-5-fluoropyridin-4-amine 95%
10gm:
$ 812.95

Apolloscientific
4-Amino-2-chloro-5-fluoropyridine
1g
$ 180.00

Ambeed
2-Chloro-5-fluoro-4-pyridinamine 97%
5g
$ 352.00

Total 51 raw suppliers

Chemical Property of 4-amino-2-chloro-5-fluoropyridine

Chemical Property:

Vapor Pressure:0.008mmHg at 25°C
Melting Point:110-111 °C(Solv: water (7732-18-5))
Boiling Point:266.982ºC at 760 mmHg
PKA:2.81±0.42(Predicted)
Flash Point:115.267ºC
PSA：38.91000
Density:1.45g/cm3
LogP:2.03750
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-chloro-5-fluoropyridin-4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-amino-2-chloro-5-fluoropyridine

There total 6 articles about 4-amino-2-chloro-5-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

: 1354223-67-8
tert-butyl (2-chloro-5-fluoropyridin-4-yl)carbamate

: 89510-90-7
4-amino-2-chloro-5-fluoropyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 91.0%

: 405230-80-0
2-chloro-5-fluoro-4-nitropyridine-1-oxide

: 89510-90-7
4-amino-2-chloro-5-fluoropyridine

Guidance literature:: With hydrogen; nickel; In ethanol; for 3h; under 2068.59 Torr;
DOI:10.1081/NCN-100108327

Reference yield:

: 31301-51-6
2-chloro-5-fluoropyridine

: 89510-90-7
4-amino-2-chloro-5-fluoropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 3.6 g / TFA; aq. H₂O₂ / 20 h / 70 - 75 °C

2: 59 percent / conc. H₂SO₄; KNO₃ / 2 h / 120 °C

3: 91 percent / H₂ / Raney Ni / ethanol / 3 h / 2068.59 Torr

With sulfuric acid; hydrogen; dihydrogen peroxide; potassium nitrate; trifluoroacetic acid; nickel; In ethanol;
DOI:10.1081/NCN-100108327