2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

Base Information

Chemical Name:2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine
CAS No.:1334407-22-5
Molecular Formula:C₁₈H₁₃Cl₂FN₆
Molecular Weight:403.246
Hs Code.:

Synonyms:2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

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Chemical Property of 2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

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Technology Process of 2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

There total 8 articles about 2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 461-98-3
4-amino-2,6-dimethylpyrimidine

: 1334411-83-4
4-bromo-2-(2,6-dichlorophenyl)-7-fluoro-1H-imidazo[4,5-c]pyridine

: 1334407-22-5
2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; at 170 ℃; for 2h; Inert atmosphere; microwave irradiation;

Reference yield:

: 405230-80-0
2-chloro-5-fluoro-4-nitropyridine-1-oxide

: 1334407-22-5
2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / Raney nickel / ethanol / 3 h / 2068.65 Torr

2.1: potassium nitrate; sulfuric acid / 1.17 h / 0 - 20 °C

2.2: 12 h / 20 °C

2.3: 5 °C / Cooling with ice

3.1: hydrogen / Raney nickel / ethanol / 2 h / 1861.78 Torr

4.1: oxygen; iron(III) chloride / 1,4-dioxane; ethanol / 10 h / 75 °C

4.2: Cooling with ice

5.1: trimethylsilyl bromide / propiononitrile / 12 h / 120 °C

5.2: 23 °C / Cooling with ice

6.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; 1,2-dimethoxyethane / 2 h / 170 °C / Inert atmosphere; microwave irradiation

With iron(III) chloride; trimethylsilyl bromide; sulfuric acid; hydrogen; oxygen; caesium carbonate; potassium nitrate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; propiononitrile;

Reference yield:

: 31301-51-6
2-chloro-5-fluoropyridine

: 1334407-22-5
2-(2,6-dichlorophenyl)-N-(2,6-dimethylpyrimidin-4-yl)-7-fluoro-1H-imidazo[4,5-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluoroacetic acid; dihydrogen peroxide / water / 70 - 75 °C

2.1: potassium nitrate; sulfuric acid / 2 h / 120 °C

2.2: 15 °C / Cooling with ice

3.1: hydrogen / Raney nickel / ethanol / 3 h / 2068.65 Torr

4.1: potassium nitrate; sulfuric acid / 1.17 h / 0 - 20 °C

4.2: 12 h / 20 °C

4.3: 5 °C / Cooling with ice

5.1: hydrogen / Raney nickel / ethanol / 2 h / 1861.78 Torr

6.1: oxygen; iron(III) chloride / 1,4-dioxane; ethanol / 10 h / 75 °C

6.2: Cooling with ice

7.1: trimethylsilyl bromide / propiononitrile / 12 h / 120 °C

7.2: 23 °C / Cooling with ice

8.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; 1,2-dimethoxyethane / 2 h / 170 °C / Inert atmosphere; microwave irradiation

With iron(III) chloride; trimethylsilyl bromide; sulfuric acid; hydrogen; dihydrogen peroxide; oxygen; caesium carbonate; potassium nitrate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; propiononitrile;