N-(2-chloro-5-luoropyridin-4-yl)nitraMide

Base Information

• Chemical Name: N-(2-chloro-5-luoropyridin-4-yl)nitraMide
• CAS No.: 405230-86-6
• Molecular Formula: C5H3ClFN3O2
• Molecular Weight: 191.55
• Mol file: 405230-86-6.mol

Synonyms:2-chloro-5-fluoro-4-nitraminopyridine;

Chemical Property of N-(2-chloro-5-luoropyridin-4-yl)nitraMide

Chemical Property:

• Melting Point: 160 °C (decomp)
• Boiling Point: 285.0±50.0 °C(Predicted)
• PKA: 3.90±0.50(Predicted)
• PSA: 70.74000
• Density: 1.672±0.06 g/cm3(Predicted)
• LogP: 2.07390

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2-CHLORO-5-FLUOROPYRIDIN-4-YL)NITRAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-chloro-5-luoropyridin-4-yl)nitraMide

There total 5 articles about N-(2-chloro-5-luoropyridin-4-yl)nitraMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-amino-2-chloro-5-fluoropyridine (89510-90-7) → 2-chloro-5-fluoro-4-nitraminopyridine (405230-86-6)

Guidance literature:

With sulfuric acid; potassium nitrate; at 0 - 20 ℃;

DOI:10.1081/NCN-100108327

Reference yield: 83.0%

→ 2-chloro-5-fluoro-4-nitraminopyridine (405230-86-6)

Guidance literature:

Reference yield:

2-chloro-5-fluoropyridine (31301-51-6) → 2-chloro-5-fluoro-4-nitraminopyridine (405230-86-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 3.6 g / TFA; aq. H₂O₂ / 20 h / 70 - 75 °C

2: 59 percent / conc. H₂SO₄; KNO₃ / 2 h / 120 °C

3: 91 percent / H₂ / Raney Ni / ethanol / 3 h / 2068.59 Torr

4: 83 percent / conc. H₂SO₄; KNO₃ / 0 - 20 °C

With sulfuric acid; hydrogen; dihydrogen peroxide; potassium nitrate; trifluoroacetic acid; nickel; In ethanol;

DOI:10.1081/NCN-100108327

upstream raw materials:

4-amino-2-chloro-5-fluoropyridine

2-chloro-5-fluoropyridine

2-chloro-5-fluoropyridine-1-oxide

2-chloro-5-fluoro-4-nitropyridine-1-oxide

Downstream raw materials:

4-amino-2-chloro-5-fluoro-3-nitropyridine

3-deaza-3-fluoro-adenosine

4-chloro-7-fluoro-1H-imidazo[4,5-c]pyridine

2-chloro-3,4-diamino-5-fluoropyridine

Refernces

• 1、 Liu,Luo,Mozdziesz,Lin,Dutschman,Gullen,Cheng,Sartorelli. "Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents". . p. 1975 - 2000. Retrieved 2007/10/03.