1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester

Base Information

• Chemical Name: 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
• CAS No.: 942190-61-6
• Molecular Formula: C11H19NO5
• Molecular Weight: 245.27556
• Mol file: 942190-61-6.mol

Synonyms:1,3-Pyrrolidinedicarboxylic acid,3-hydroxy-,1-(1,1-dimethylethyl) 3-methyl ester; 1-tert-Butyl-3-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate

Chemical Property of 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester

Chemical Property:

• Boiling Point: 314.5±42.0 °C(Predicted)
• PKA: 12.57±0.20(Predicted)
• PSA: 76.07000
• Density: 1.226±0.06 g/cm3(Predicted)
• LogP: 0.46920
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Methyl1-Boc-3-hydroxypyrrolidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-tert-Butyl-3-Methyl 3-Hydroxypyrrolidine-1,3-Dicarboxylate can be used as LRRK2 inhibitors to treat diseases in which LRRK2 kinase is involved.

Technology Process of 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester

There total 3 articles about 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methanol (67-56-1) + di-tert-butyl dicarbonate (24424-99-5) → 1-(tert-butyl) 3-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate (942190-61-6)

Guidance literature:

methanol; tert-butyl 3-cyano-3-((trimethylsilyl)oxy)pyrrolidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 70 ℃;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl 3-hydroxypyrrolidine-3-carboxylate hydrochloride → 1-(tert-butyl) 3-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate (942190-61-6)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 8h;

Reference yield:

3-cyano-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (1194376-31-2) → 1-(tert-butyl) 3-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate (942190-61-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

2: sodium hydrogencarbonate / water; ethyl acetate / 8 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; water; ethyl acetate;

upstream raw materials:

methanol

di-tert-butyl dicarbonate

3-cyano-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

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