4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS No.: 925436-46-0
• Molecular Formula: C₃₀H₃₁N₇O₃S
• Molecular Weight: 569.687
• Hs Code.: 2934100090
• Mol file: 925436-46-0.mol

Synonyms:4-[[6-[2-[(2-quinoxalinylcarbonyl)amino]phenyl]imidazo [2,1-b]thiazol-3-yl]methyl]-1-Piperazine carbocylic acid 1,1-dimethylethyl ester; tert-Butyl 4-((6-(2-(quinoxaline-2-carboxamido)phenyl)imidazo[2,1-b]thiazol-3-yl)methyl)piperazine-1-carboxylate; tert-Butyl 4-((6-(2-(quinoxaline-2-carboxamido)phenyl)imidazo-[2,1-b]thiazol-3-yl)methyl)piperazine-1-carboxylate

Chemical Property of 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PKA: 11.19±0.70(Predicted)
• PSA: 133.20000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 5.25980
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-((6-(2-(quinoxaline-2-carboxamido)phenyl)imidazo-[2,1-b]thiazol-3-yl)methyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

There total 6 articles about 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinoxaline-2-carboxylic acid chloride (54745-92-5) + 4-[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-ylmethyl]piperazine-1-carboxylic acid tert-butyl ester (925437-87-2) → C30H31N7O3S (925436-46-0)

Guidance literature:

With pyridine; at 160 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

(6-(2-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)methanol (925437-85-0) → C30H31N7O3S (925436-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

2.1: triethylamine / acetonitrile / 24 h / 20 °C

2.2: 24 h / Heating / reflux

3.1: pyridine / 0.17 h / 160 °C / microwave irradiation

With pyridine; triethylamine; In dichloromethane; acetonitrile;

Reference yield:

6-(2-nitrophenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester (925437-84-9) → C30H31N7O3S (925436-46-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 3 h / 0 °C

2.2: 0.75 h / 0 °C

3.1: triethylamine / dichloromethane / 0.25 h / 20 °C

4.1: triethylamine / acetonitrile / 24 h / 20 °C

4.2: 24 h / Heating / reflux

5.1: pyridine / 0.17 h / 160 °C / microwave irradiation

With 4-methyl-morpholine; pyridine; sodium hydroxide; water; triethylamine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

quinoxaline-2-carboxylic acid chloride

4-[6-(2-aminophenyl)imidazo[2,1-b]thiazol-3-ylmethyl]piperazine-1-carboxylic acid tert-butyl ester

(6-(2-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)methanol

6-(2-nitrophenyl)-imidazo[2,1-b]thiazole-3-carboxylic acid ethyl ester

Downstream raw materials:

SRT1720

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