Ethyl 2-[benzyl(phenyl)amino]acetate

Base Information

• Chemical Name: Ethyl 2-[benzyl(phenyl)amino]acetate
• CAS No.: 49790-83-2
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.343
• DSSTox Substance ID: DTXSID40508696
• Wikidata: Q82365829
• Mol file: 49790-83-2.mol

Synonyms:49790-83-2;ETHYL 2-[BENZYL(PHENYL)AMINO]ACETATE;ethyl 2-(N-benzylanilino)acetate;Ethyl 2-(benzyl(phenyl)amino)acetate;Glycine, N-phenyl-N-(phenylmethyl)-, ethylester;SCHEMBL17700288;Ethyl N-benzyl-N-phenylglycinate;DTXSID40508696;YFBKHZQXIGOLKS-UHFFFAOYSA-N;FT-0749854

Chemical Property of Ethyl 2-[benzyl(phenyl)amino]acetate

Chemical Property:

• PSA: 29.54000
• LogP: 3.25630
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 269.141578849
• Heavy Atom Count: 20
• Complexity: 281

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CN(CC1=CC=CC=C1)C2=CC=CC=C2

Technology Process of Ethyl 2-[benzyl(phenyl)amino]acetate

There total 6 articles about Ethyl 2-[benzyl(phenyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

diazoacetic acid ethyl ester (623-73-4) + N-Benzylaniline (758640-21-0,103-32-2) → ethyl 2-(N-benzyl-N-phenylamino)acetate (49790-83-2)

Guidance literature:

With [2-(4-hydroxymethyl)phenyl-4,4-(dimethyloxazole)Ru(CH₃CN)₄]PF₆; In diethyl ether; water; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2017.10.062

Reference yield:

N-phenylglycine ethyl ester (2216-92-4) + benzyl bromide (100-39-0) → ethyl 2-(N-benzyl-N-phenylamino)acetate (49790-83-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

N-phenylglycine ethyl ester (2216-92-4) + benzyl chloride (100-44-7) → ethyl 2-(N-benzyl-N-phenylamino)acetate (49790-83-2)

Guidance literature:

With toluene;

DOI:10.1021/ja01158a026

upstream raw materials:

N-phenylglycine ethyl ester

benzyl chloride

N-Benzylaniline

ethyl bromoacetate

Downstream raw materials:

N-phenylglycine ethyl ester

ethyl dipheny phenylalaninate