(2E)-2-[4-Oxo-1-trityl-3-piperidinylidene]acetic Acid Ethyl Ester

Base Information

• Chemical Name: (2E)-2-[4-Oxo-1-trityl-3-piperidinylidene]acetic Acid Ethyl Ester
• CAS No.: 239466-39-8
• Molecular Formula: C28H27NO3
• Molecular Weight: 425.527
• Mol file: 239466-39-8.mol

Synonyms:(2E)-2-[4-Oxo-1-trityl-3-piperidinylidene]acetic Acid Ethyl Ester;(2E)-[4-Oxo-1-(triphenylMethyl)-3-piperidinylidene]acetic acid Ethyl Ester

Chemical Property of (2E)-2-[4-Oxo-1-trityl-3-piperidinylidene]acetic Acid Ethyl Ester

Chemical Property:

• Boiling Point: 546.8±50.0 °C(Predicted)
• PKA: 3.09±0.20(Predicted)
• PSA: 46.61000
• Density: 1.205±0.06 g/cm3(Predicted)
• LogP: 4.68070
• Solubility.: Chloroform, Dichloromethane, Ether, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

(2E)-2-[4-Oxo-1-trityl-3-piperidinylidene]aceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation Oxo Clopidogrel MPB Derivative.

Technology Process of (2E)-2-[4-Oxo-1-trityl-3-piperidinylidene]acetic Acid Ethyl Ester

There total 3 articles about (2E)-2-[4-Oxo-1-trityl-3-piperidinylidene]acetic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.2%

glyoxylic acid ethyl ester (924-44-7) + 1-triphenylmethyl-4-piperidone (112257-60-0) → E-2-(4-carbonyl-1-tritylpiperidin-3-ylidene)ethyl acetate (239466-39-8)

Guidance literature:

1-triphenylmethyl-4-piperidone; With pyrrolidine; In toluene; for 3h; Reflux;

glyoxylic acid ethyl ester; In toluene; for 2h; Reflux;

Reference yield: 60.2%

→ E-2-(4-carbonyl-1-tritylpiperidin-3-ylidene)ethyl acetate (239466-39-8)

Guidance literature:

Reference yield:

trityl chloride (76-83-5) → E-2-(4-carbonyl-1-tritylpiperidin-3-ylidene)ethyl acetate (239466-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 5 h / 60 °C

2.1: pyrrolidine / toluene / 3 h / Reflux

2.2: 2 h / Reflux

With pyrrolidine; triethylamine; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

trityl chloride

glyoxylic acid ethyl ester

1-triphenylmethyl-4-piperidone

Downstream raw materials:

ethyl (E)-2-(4-hydroxy-1-tritylpiperidin-3-ylidene)acetate

2-[(3E)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-mercaptopiperidine-3-ylidene]acetic acid

R-361015

R-130964