Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 19,19-bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonade c-1-yl ester

Base Information

• Chemical Name: Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 19,19-bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonade c-1-yl ester
• CAS No.: 125607-09-2
• Molecular Formula: C42H61N2O10P
• Molecular Weight: 784.928
• Mol file: 125607-09-2.mol

Synonyms:

Chemical Property of Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 19,19-bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonade c-1-yl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 19,19-bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonade c-1-yl ester

There total 4 articles about Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 19,19-bis(4-methoxyphenyl)-19-phenyl-3,6,9,12,15,18-hexaoxanonade c-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.2%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 17-<(4,4'-dimethoxytrityl)oxy>-3,6,9,12,15-pentaoxaheptadecan-1-ol (123706-69-4) → 1-O-DMT-6-β-cyanoethyl-N,N-diisopropylphosphoramidite-hexaethylene glycol (125607-09-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 4 ℃; for 0.333333h;

Reference yield:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 17-<(4,4'-dimethoxytrityl)oxy>-3,6,9,12,15-pentaoxaheptadecan-1-ol (123706-69-4) → 1-O-DMT-6-β-cyanoethyl-N,N-diisopropylphosphoramidite-hexaethylene glycol (125607-09-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 2h;

DOI:10.1016/S0960-894X(01)00760-0

Reference yield:

pentaethylene glycol (2615-15-8) → 1-O-DMT-6-β-cyanoethyl-N,N-diisopropylphosphoramidite-hexaethylene glycol (125607-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 4 h / 0 - 20 °C

2: DIPEA / 2 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/S0960-894X(01)00760-0

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

17-<(4,4'-dimethoxytrityl)oxy>-3,6,9,12,15-pentaoxaheptadecan-1-ol

pentaethylene glycol

4,4'-dimethoxytrityl chloride