1H-Indazole-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1H-Indazole-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
• CAS No.: 882188-87-6
• Molecular Formula: C₁₃H₁₆N₂O₃
• Molecular Weight: 248.282
• Hs Code.: 2933990090
• Mol file: 882188-87-6.mol

Synonyms:3-(Hydroxymethyl)-1H-indazole,N1-BOCprotected;tert-Butyl 3-(hydroxymethyl)-1H-indazole-1-carboxylate;3-Hydroxymethyl-indazole-1-carboxylic acid tert-butyl ester;1H-Indazole-1-carboxylic acid, 3-(hydroxyMethyl)-, 1,1-diMethylethyl ester

Chemical Property of 1H-Indazole-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 64.35000
• LogP: 2.31180
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(hydroxymethyl)-1H-indazole-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester

There total 4 articles about 1H-Indazole-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-tert-butoxycarbonyl-3-indazolecarboxylic acid methyl ester → tert-butyl 3-(hydroxymethyl)-1H-indazole-1-carboxylate (882188-87-6)

Guidance literature:

1-tert-butoxycarbonyl-3-indazolecarboxylic acid methyl ester; With sodium tetrahydroborate; cerium(III) chloride heptahydrate; In ethanol; at 20 ℃; for 18h;

With hydrogenchloride; In water; Reagent/catalyst; Solvent;

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(hydroxymethyl)-1H-indazole (64132-13-4) → tert-butyl 3-(hydroxymethyl)-1H-indazole-1-carboxylate (882188-87-6)

Guidance literature:

With dmap; sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

1H-Indazole-3-carboxylic acid (4498-67-3) → tert-butyl 3-(hydroxymethyl)-1H-indazole-1-carboxylate (882188-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / LiAlH₄ / tetrahydrofuran / 0 °C

2: 60 percent / tetrahydrofuran

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/j.bmc.2005.10.022

upstream raw materials:

di-tert-butyl dicarbonate

3-(hydroxymethyl)-1H-indazole

1H-Indazole-3-carboxylic acid

methyl 1H-indazole-3-carboxylate

Downstream raw materials:

tert-butyl 3-formyl-1H-indazole-1-carboxylate

2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate