64132-13-4Relevant articles and documents
Supramolecular luminescent lanthanide dimers for fluoride sequestering and sensing
Liu, Tao,Nonat, Aline,Beyler, Maryline,Regueiro-Figueroa, Martín,Nchiminono, Katia,Jeannin, Olivier,Camerel, Franck,Debaene, Fran?ois,Cianférani-Sanglier, Sarah,Tripier, Rapha?l,Platas-Iglesias, Carlos,Charbonnière, Lo?c J.
, p. 7259 - 7263 (2014)
Lanthanide complexes (Ln=Eu, Tb, and Yb) that are based on a C 2-symmetric cyclen scaffold were prepared and characterized. The addition of fluoride anions to aqueous solutions of the complexes resulted in the formation of dinuclear supramolecular compounds in which the anion is confined into the cavity that is formed by the two complexes. The supramolecular assembly process was monitored by UV/Vis absorption, luminescence, and NMR spectroscopy and high-resolution mass spectrometry. The X-ray crystal structure of the europium dimer revealed that the architecture of the scaffold is stabilized by synergistic effects of the Eu-F-Eu bridging motive, πstacking interactions, and a four-component hydrogen-bonding network, which control the assembly of the two [EuL] entities around the fluoride ion. The strong association in water allowed for the luminescence sensing of fluoride down to a detection limit of 24nM.
Anticancer activity evaluation of indazolyl-substituted piperidin-4-yl-aminopyrimidines
Wang, Chao,Liu, Xiao-Wen,Xiao, Ting,Xu, Zhi-Qiang,Cao, Shuang,Wang, Hai-Feng,Yan, Qiong-Jiao,Gu, Shuang-Xi,Zhu, Yuan-Yuan
, p. 910 - 915 (2020)
Based on our previous work, a series of indazolyl-substituted piperidin-4-yl-aminopyrimidines, which were firstly used as anti-HIV agents, were evaluated for their anticancer potency in five cancer cell lines. Notably, they exhibited excellent activities
Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities
Xiao, Ting,Tang, Jia-Fan,Meng, Ge,Pannecouque, Christophe,Zhu, Yuan-Yuan,Liu, Gen-Yan,Xu, Zhi-Qiang,Wu, Feng-Shou,Gu, Shuang-Xi,Chen, Fen-Er
, (2019/12/09)
A series of indazolyl-substituted piperidin-4-yl-aminopyrimidines (IPAPYs) were designed from two potent HIV-1 NNRTIs piperidin-4-yl-aminopyrimidine 3c and diaryl ether 4 as the lead compounds by molecular hybridization strategy. The target molecules 5a-q
EPHA4 CYCLIC PEPTIDE ANTAGONISTS AND METHODS OF USE THEREOF
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Paragraph 0632-0633; 0635, (2019/11/19)
Disclosed herein are compounds and methods of use thereof for the modulation of EphA4 receptor activity. In an aspect, is provided a method of treating or preventing a disease or disorder mediated by EphA4, comprising administering to a subject in need thereof a therapeutically effective amount of a compound as described herein, including certain embodiments, or the structural Formula (I), (l-A), (II), (III), (IV), (IV-1), (V), (Vl-A), (Vl-B), (VII-1), (VII-2), (VIII-1), or (VIII-2), or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof.