1-[(4-Methoxyphenyl)methyl]-3-(phenylseleno)-2-piperidinone

Base Information

• Chemical Name: 1-[(4-Methoxyphenyl)methyl]-3-(phenylseleno)-2-piperidinone
• CAS No.: 128773-77-3
• Molecular Formula: C₁₉H₂₁NO₂Se
• Molecular Weight: 374.341
• DSSTox Substance ID: DTXSID101188537
• Mol file: 128773-77-3.mol

Synonyms:1-[(4-Methoxyphenyl)methyl]-3-(phenylseleno)-2-piperidinone;DTXSID101188537;128773-77-3

Chemical Property of 1-[(4-Methoxyphenyl)methyl]-3-(phenylseleno)-2-piperidinone

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 375.07375
• Heavy Atom Count: 23
• Complexity: 376

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CN2CCCC(C2=O)[Se]C3=CC=CC=C3

Technology Process of 1-[(4-Methoxyphenyl)methyl]-3-(phenylseleno)-2-piperidinone

There total 3 articles about 1-[(4-Methoxyphenyl)methyl]-3-(phenylseleno)-2-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → 1-(4-Methoxy-benzyl)-3-phenylselanyl-piperidin-2-one (128773-77-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 1) lithium diisopropylamide, 2) hexamethylphosphoramide / 1) THF, hexane, -78 deg C, 35 min, 2) THF, -78 deg C, 30 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;

DOI:10.1021/jo00048a021

Reference yield:

piperidin-2-one (675-20-7) → 1-(4-Methoxy-benzyl)-3-phenylselanyl-piperidin-2-one (128773-77-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 1) lithium diisopropylamide, 2) hexamethylphosphoramide / 1) THF, hexane, -78 deg C, 35 min, 2) THF, -78 deg C, 30 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;

DOI:10.1021/jo00048a021

Reference yield:

p-methoxybenzyl tosylate (14670-03-2) → 1-(4-Methoxy-benzyl)-3-phenylselanyl-piperidin-2-one (128773-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / NaH

2: 94 percent / 1.) lithium diisopropylamide

With sodium hydride; lithium diisopropyl amide;

DOI:10.1016/S0040-4039(00)88731-6

upstream raw materials:

piperidin-2-one

4-Methoxybenzyl alcohol

p-methoxybenzyl tosylate

Downstream raw materials:

1-(4-methoxybenzyl)-5,6-dihydropyridin-2(1H)-one

2-(p-methoxbenzyl)-1,2,3,4-tetrahydro-5,11-dimethylpyrido<4,3-b>carbazole

2-(p-methoxybenzyl)-3,4-dihydro-5,11-dimethyl-1-oxopyrido<4,3-b>carbazole