2,2-dimethyl-5-((thiophen-3-ylamino)methylene)-1,3-dioxane-4,6-dione

Base Information

• Chemical Name: 2,2-dimethyl-5-((thiophen-3-ylamino)methylene)-1,3-dioxane-4,6-dione
• CAS No.: 913377-45-4
• Molecular Formula: C11H11NO4S
• Molecular Weight: 253.279
• Hs Code.: 2934999090
• Mol file: 913377-45-4.mol

Synonyms:2,2-dimethyl-5-[(thiophen-3-ylamino)methylidene]-1,3-dioxane-4,6-dione;

Chemical Property of 2,2-dimethyl-5-((thiophen-3-ylamino)methylene)-1,3-dioxane-4,6-dione

Chemical Property:

• PSA: 92.87000
• LogP: 1.95300
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,2-Dimethyl-5-((thiophen-3-ylamino)methylene)-1,3-dioxane-4,6-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-dimethyl-5-((thiophen-3-ylamino)methylene)-1,3-dioxane-4,6-dione

There total 3 articles about 2,2-dimethyl-5-((thiophen-3-ylamino)methylene)-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

cycl-isopropylidene malonate (2033-24-1) + 3-aminothiophene (17721-06-1) + orthoformic acid triethyl ester (122-51-0) → 2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione (913377-45-4)

Guidance literature:

cycl-isopropylidene malonate; orthoformic acid triethyl ester; In isopropyl alcohol; at 100 ℃; for 1h;

3-aminothiophene; In isopropyl alcohol; for 0.5h; Reflux;

Reference yield: 73.0%

cycl-isopropylidene malonate (2033-24-1) + thiophen‐3‐amine oxalate (861965-63-1) → 2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione (913377-45-4)

Guidance literature:

orthoformic acid triethyl ester; thiophen‐3‐amine oxalate; for 0.25h;

cycl-isopropylidene malonate; at 85 ℃;

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + 3-aminothiophene (17721-06-1) + trimethyl orthoformate (149-73-5) → 2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione (913377-45-4)

Guidance literature:

cycl-isopropylidene malonate; trimethyl orthoformate; With potassium carbonate; at 30 ℃; for 1h;

3-aminothiophene; at 20 - 85 ℃; for 15h;

With potassium carbonate; In dichloromethane; for 0.5h;

upstream raw materials:

cycl-isopropylidene malonate

thiophen‐3‐amine oxalate

3-aminothiophene

trimethyl orthoformate

Downstream raw materials:

thieno[3,2-b]pyridin-7-ol

thieno[3,2-b]pyridin-7(4H)-one

7-chlorothieno[3,2-b]pyridine

2-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-b]pyridin-7-amine