4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

Base Information

Chemical Name:4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde
CAS No.:1228102-90-6
Molecular Formula:C₂₈H₂₂N₂O₃S
Molecular Weight:466.56
Hs Code.:

Synonyms:4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

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Chemical Property of 4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

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Technology Process of 4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

There total 9 articles about 4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1228102-89-3
2-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-b]pyridin-7-amine

: 87199-17-5
4-formylphenylboronic acid,

: 1228102-90-6
4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 15h; Inert atmosphere;

Reference yield:

: 69627-03-8
7-chlorothieno[3,2-b]pyridine

: 1228102-90-6
4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 20 °C

2.1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

With n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; diisopropylamine; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: |Suzuki Coupling;

Reference yield:

: 913377-45-4
2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione

: 1228102-90-6
4-(7-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-b]pyridin-2-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenylether / 0.5 h / 259 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; 1,2-dichloro-ethane / 6 h / Reflux

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 - 20 °C

4.1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

5.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diphenylether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 5.1: |Suzuki Coupling;