4-Methylthiopiperidine hydrochloride

Base Information

• Chemical Name: 4-Methylthiopiperidine hydrochloride
• CAS No.: 208245-70-9
• Molecular Formula: C6H13NS.ClH
• Molecular Weight: 167.70006
• Hs Code.: 2933399090
• Mol file: 208245-70-9.mol

Synonyms:4-(Methylsulfanyl)piperidine hydrochloride (1:1); Piperidine, 4-(methylthio)-, hydrochloride (1:1)

Chemical Property of 4-Methylthiopiperidine hydrochloride

Chemical Property:

• PSA: 37.33000
• LogP: 2.23220
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-MethylthiopiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methylthiopiperidine hydrochloride

There total 3 articles about 4-Methylthiopiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylsulfanylpiperidine-1-carboxylic acid tert-butyl ester (208245-69-6) → 4-(methylthio)piperidine hydrochloride (208245-70-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; for 0.0333333h; Reflux;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(methylthio)piperidine hydrochloride (208245-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2.17 h / 0 - 20 °C

2: methanol / 15 h / Reflux

3: hydrogenchloride / 1,4-dioxane; methanol / 0.03 h / Reflux

With hydrogenchloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate (141699-59-4) → 4-(methylthio)piperidine hydrochloride (208245-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 15 h / Reflux

2: hydrogenchloride / 1,4-dioxane; methanol / 0.03 h / Reflux

With hydrogenchloride; In 1,4-dioxane; methanol;

upstream raw materials:

4-methylsulfanylpiperidine-1-carboxylic acid tert-butyl ester

t-butyl 4-hydroxy piperidine-1-carboxylate

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

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