Unii-33o78xf0bw

Base Information

Chemical Name:Unii-33o78xf0bw
CAS No.:635728-49-3
Molecular Formula:C27H37N3O7S.C2H6O
Molecular Weight:593.742
Hs Code.:29334900
Mol file:635728-49-3.mol

Synonyms:Darunavir ethanolate;

Suppliers and Price of Unii-33o78xf0bw

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Darunavir Ethanolate
5mg
$ 460.00

TRC
DarunavirEthanolate
5mg
$ 150.00

TRC
DarunavirEthanolate
50mg
$ 770.00

ChemScene
DarunavirEthanolate 99.92%
100mg
$ 500.00

ChemScene
DarunavirEthanolate 99.92%
50mg
$ 280.00

ChemScene
DarunavirEthanolate 99.92%
10mg
$ 90.00

ChemScene
DarunavirEthanolate 99.92%
5mg
$ 50.00

Biosynth Carbosynth
Darunavir Ethanolate
250 mg
$ 100.00

Biosynth Carbosynth
Darunavir Ethanolate
100 mg
$ 50.00

Biosynth Carbosynth
Darunavir Ethanolate
1 g
$ 225.00

Total 82 raw suppliers

Chemical Property of Unii-33o78xf0bw

Chemical Property:

Appearance/Colour:White Solid
Melting Point:98-100°C
PSA：169.03000
LogP:4.42680
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Darunavir Ethanolate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Darunavir Ethanolate(Prezista) is an inhibitor of HIV protease. [1] Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutati Darunavir Ethanolate (Prezista) is an HIV protease inhibitor. Derivative of Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.

Technology Process of Unii-33o78xf0bw

There total 10 articles about Unii-33o78xf0bw which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 64-17-5
ethanol

: 206361-99-1
darunavir

: 635728-49-3
[14C]-Darunavir ethanolate

Guidance literature:: at 75 - 80 ℃;
DOI:10.1007/s11164-019-03948-4

Reference yield: 82.5%

: 64-17-5
ethanol

: 192725-55-6,252873-01-1,252873-35-1
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(4-nitrophenyl)carbonic acid

: 169280-56-2
4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

: 635728-49-3
[14C]-Darunavir ethanolate

Guidance literature:: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl-(4-nitrophenyl)carbonic acid; 4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide; In 1-methyl-pyrrolidin-2-one; at -4 - 30 ℃; for 10h;

ethanol; at 45 - 50 ℃; for 1h;

Reference yield:

: 191226-98-9
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

: 635728-49-3
[14C]-Darunavir ethanolate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; triethanolamine / palladium 10% on activated carbon / methanol / 2 h / 40 - 45 °C

2.1: hydrogenchloride; water / 2 h / Reflux

3.1: 1-methyl-pyrrolidin-2-one / 10 h / -4 - 30 °C

3.2: 1 h / 45 - 50 °C

With hydrogenchloride; triethanolamine; water; hydrogen; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol;