2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid

Base Information

• Chemical Name: 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid
• CAS No.: 385449-77-4
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.20378
• Mol file: 385449-77-4.mol

Synonyms:3-Pyridineacetic acid, 6-amino-α,α-dimethyl-;2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid

Chemical Property of 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid

Chemical Property:

• PSA: 76.21000
• LogP: 1.60720

Purity/Quality:

6-amino-a,a-dimethyl-3-Pyridineaceticacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid

There total 7 articles about 2-(6-aMinopyridin-3-yl)-2-Methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 2-[6-(2,2-dimethyl-4-oxo-4H-1,3-benzoxazin-3-yl)-pyridin-3-yl]-2-methylpropanoate (246219-77-2) → 2-(6-amino-pyridin-3-yl)-2-methyl-propionic acid (385449-77-4)

Guidance literature:

hydrogenchloride; at 100 ℃; for 8h;

DOI:10.1016/S0040-4039(01)01322-3

Reference yield:

ethyl 2-methyl-2-(pyridin-3-yl)propionate (120690-70-2) → 2-(6-amino-pyridin-3-yl)-2-methyl-propionic acid (385449-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / m-CPBA; NaHCO₃ / CHCl₃; H₂O / 12 h / 20 °C

2: 84 percent / 1,2-dichloro-ethane / 72 h / 82 °C

3: 88 percent / HCl / 8 h / 100 °C

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; hydrogenchloride; In chloroform; water; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4039(01)01322-3

Reference yield:

2-methyl-2-(1-oxy-pyridin-3-yl)-propionic acid ethyl ester (169253-21-8) → 2-(6-amino-pyridin-3-yl)-2-methyl-propionic acid (385449-77-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 1,2-dichloro-ethane / 72 h / 82 °C

2: 88 percent / HCl / 8 h / 100 °C

hydrogenchloride; In 1,2-dichloro-ethane;

DOI:10.1016/S0040-4039(01)01322-3

upstream raw materials:

ethyl 2-[6-(2,2-dimethyl-4-oxo-4H-1,3-benzoxazin-3-yl)-pyridin-3-yl]-2-methylpropanoate

ethyl 2-methyl-2-(pyridin-3-yl)propionate

2-methyl-2-(1-oxy-pyridin-3-yl)-propionic acid ethyl ester

5-bromo-2-pyridylamine

Downstream raw materials:

5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-3-[1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester

(S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one

(S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-hydroxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one

(S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-amino-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one