Methyl 2-(5-broMopyridin-2-yl)acetate

Base Information

• Chemical Name: Methyl 2-(5-broMopyridin-2-yl)acetate
• CAS No.: 917023-06-4
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.061
• Hs Code.: 2933399090
• Mol file: 917023-06-4.mol

Synonyms:methyl 5-bromopyridine-2-acetate; (5-bromo-pyridin-2-yl)-acetic acid methyl ester; (5-bromo-2-pyridinyl)-acetic acid methyl ester

Chemical Property of Methyl 2-(5-broMopyridin-2-yl)acetate

Chemical Property:

• Boiling Point: 266.0±25.0 °C(Predicted)
• PKA: 1.95±0.22(Predicted)
• PSA: 39.19000
• Density: 1.517±0.06 g/cm3(Predicted)
• LogP: 1.55960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(5-Bromopyridin-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(5-broMopyridin-2-yl)acetate

There total 8 articles about Methyl 2-(5-broMopyridin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + 2-(5-bromopyridin-2-yl)acetic acid (192642-85-6) → methyl 2-(5-bromopyridin-2-yl)acetate (917023-06-4)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 3h;

Reference yield: 72.0%

5-(5-bromo-1H-2-pyridinylidene)-2,2-dimethyl-[1,3]dioxane-4',6-dione (192642-83-4) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-(5-bromopyridin-2-yl)acetate (917023-06-4)

Guidance literature:

5-(5-bromo-1H-2-pyridinylidene)-2,2-dimethyl-[1,3]dioxane-4',6-dione; With hydrogenchloride; water; In 1,4-dioxane; at 100 ℃; for 1h;

diazomethyl-trimethyl-silane; In methanol; diethyl ether; toluene; at 20 ℃; for 0.5h;

Reference yield: 72.0%

methanol (67-56-1) + 2-(5-bromopyridin-2-yl)acetonitrile (312325-72-7) → methyl 2-(5-bromopyridin-2-yl)acetate (917023-06-4)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1021/acs.jmedchem.8b00164

upstream raw materials:

5-(5-bromo-1H-2-pyridinylidene)-2,2-dimethyl-[1,3]dioxane-4',6-dione

diazomethyl-trimethyl-silane

methanol

2-(5-bromopyridin-2-yl)acetic acid

Downstream raw materials:

methyl 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetate