tert-Butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate
• CAS No.: 912768-78-6
• Molecular Formula: C18H25NO3
• Molecular Weight: 303.4
• Hs Code.: 2933399090
• Mol file: 912768-78-6.mol

Synonyms:tert-butyl 4-(4-Methylphenyl)piperidine-1-carboxylate;tert-Butyl 4-(4-Methylbenzoyl)piperidine-1-carboxylate;4-(4-Methyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of tert-Butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate

Chemical Property:

• PSA: 46.61000
• LogP: 3.76270

Purity/Quality:

99% ^*data from raw suppliers

tert-butyl4-(4-Methylbenzoyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate

There total 4 articles about tert-Butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

para-bromotoluene (106-38-7) + tert butyl 4-formylpiperidine-1-carboxylate (137076-22-3) → tert-butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate (912768-78-6)

Guidance literature:

With Quinuclidine; 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]; potassium carbonate; In 1,4-dioxane; at 20 ℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/jacs.7b07078

Reference yield:

4-cyanopiperidine (4395-98-6) → tert-butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate (912768-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 79 percent / NaHCO₃ / 20 h / 20 °C

2.1: Mg; I₂ / diethyl ether / Heating

2.2: diethyl ether / Heating

With iodine; sodium hydrogencarbonate; magnesium; In diethyl ether;

DOI:10.1021/jm0309349

Reference yield:

4-carboxamidopiperidine (39546-32-2) → tert-butyl 4-(4-methylbenzoyl)piperidine-1-carboxylate (912768-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 86 percent / SOCl₂ / 3 h / Heating

2.1: 79 percent / NaHCO₃ / 20 h / 20 °C

3.1: Mg; I₂ / diethyl ether / Heating

3.2: diethyl ether / Heating

With thionyl chloride; iodine; sodium hydrogencarbonate; magnesium; In diethyl ether;

DOI:10.1021/jm0309349

upstream raw materials:

para-bromotoluene

1-tert-butoxycarbonyl-4-cyanopiperidine

4-cyanopiperidine

4-carboxamidopiperidine

Downstream raw materials:

(4-methylphenyl)(piperidin-4-yl)methanol

4-(4-methylbenzoyl)-piperidine

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