4-Isoxazolecarboxylic acid, 5-methyl-3-[4-(trifluoromethyl)phenyl]-, ethyl ester

Base Information

Chemical Name:4-Isoxazolecarboxylic acid, 5-methyl-3-[4-(trifluoromethyl)phenyl]-, ethyl ester
CAS No.:159693-08-0
Molecular Formula:C₁₄H₁₂F₃NO₃
Molecular Weight:299.249
Hs Code.:

Synonyms:5-Methyl-3-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid ethyl ester;

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Chemical Property of 4-Isoxazolecarboxylic acid, 5-methyl-3-[4-(trifluoromethyl)phenyl]-, ethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-Isoxazolecarboxylic acid, 5-methyl-3-[4-(trifluoromethyl)phenyl]-, ethyl ester

There total 4 articles about 4-Isoxazolecarboxylic acid, 5-methyl-3-[4-(trifluoromethyl)phenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 4341-76-8
Ethyl 2-butynoate

: 74467-05-3
N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

: 159693-08-0
(3-(4-trifluoromethylphenyl)-5-methyl)isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In diethyl ether; for 0.75h;
DOI:10.1021/jf00049a040

Reference yield:

: 66046-34-2
4-(trifluoromethyl)benzaldehyde oxime

: 159693-08-0
(3-(4-trifluoromethylphenyl)-5-methyl)isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 28 percent / Et₃N / diethyl ether / 0.75 h

With N-chloro-succinimide; triethylamine; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 159693-08-0
(3-(4-trifluoromethylphenyl)-5-methyl)isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / water

2: N-chloro-succinimide / N,N-dimethyl-formamide

3: ethanol

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1007/s11164-013-1062-y