2,3-Difluoro-4-pentyloxyphenylboronic acid

Base Information

• Chemical Name: 2,3-Difluoro-4-pentyloxyphenylboronic acid
• CAS No.: 156684-91-2
• Molecular Formula: C11H15BF2O3
• Molecular Weight: 244.04
• Hs Code.: 2931900090
• Mol file: 156684-91-2.mol

Synonyms:2,3-DIFLUORO-4-PENTYLOXYPHENYLBORONIC ACID;4-PENTYLOXY-2,3-DIFLUOROPHENYLBORONIC ACID

Chemical Property of 2,3-Difluoro-4-pentyloxyphenylboronic acid

Chemical Property:

• Boiling Point: 355.0±52.0 °C(Predicted)
• PKA: 7.42±0.58(Predicted)
• PSA: 49.69000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 1.21360
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(2,3-Difluoro-4-(pentyloxy)phenyl)boronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Difluoro-4-pentyloxyphenylboronic acid

There total 10 articles about 2,3-Difluoro-4-pentyloxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C17H27BF2O3 → 2,3-difluoro-4-pentyloxybenzeneboronic acid (156684-91-2)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 1h;

DOI:10.1039/a902351h

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 1,2-difluoro-3-pentyloxybenzene (156684-90-1) → 2,3-difluoro-4-pentyloxybenzeneboronic acid (156684-91-2)

Guidance literature:

1,2-difluoro-3-pentyloxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h;

Trimethyl borate; In tetrahydrofuran; hexane;

Reference yield:

2,3-difluorophenol (6418-38-8) → 2,3-difluoro-4-pentyloxybenzeneboronic acid (156684-91-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 92 percent / K₂CO₃ / acetone / 48 h / Heating

2.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

2.2: hexane; tetrahydrofuran / -78 - 20 °C

3.1: 100 percent / 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; acetone; 1.1: Alkylation / 2.1: Metallation / 2.2: Substitution / 3.1: Hydrolysis;

DOI:10.1039/a902351h

upstream raw materials:

1-Bromopentane

ortho-difluorobenzene

2,3-difluorophenol

(2,3-difluorophenyl)boronic acid