3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester
• CAS No.: 442903-28-8
• Molecular Formula: C₇H₅Cl₂NO₂
• Molecular Weight: 206.028
• Hs Code.: 2933399090
• Mol file: 442903-28-8.mol

Synonyms:3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester;4-dichloropyridine-3-carboxylate;2,4-Dichloro nicotinic acid Methyl ester;Methyl 2,4-dichloropyridine-3-carboxylate;Methyl 2,4-dichloropyridine-3-carboxylate, 2,4-Dichloro-3-(methoxycarbonyl)pyridine

Chemical Property of 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester

Chemical Property:

• Boiling Point: 266.2±35.0 °C(Predicted)
• PKA: -1.24±0.10(Predicted)
• PSA: 39.19000
• Density: 1.426±0.06 g/cm3(Predicted)
• LogP: 2.17500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2,4-dichloronicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester

There total 3 articles about 3-Pyridinecarboxylic acid, 2,4-dichloro-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4-dichloronicotinic acid (262423-77-8) → methyl 2,4-dichloronicotinate (442903-28-8)

Guidance literature:

1-methyl-1-nitrosourea; With potassium hydroxide; In diethyl ether; water;

2,4-dichloronicotinic acid; In methanol; diethyl ether; at 0 - 20 ℃; for 1h;

Reference yield: 93.0%

2,4-dichloronicotinic acid (262423-77-8) + methyl iodide (74-88-4) → methyl 2,4-dichloronicotinate (442903-28-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1016/j.tetlet.2010.11.108

Reference yield:

2,4-dichloropyridine (26452-80-2) → methyl 2,4-dichloronicotinate (442903-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.5 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;

upstream raw materials:

2,4-dichloronicotinic acid

methyl iodide

2,4-dichloropyridine

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