tert-butyl oxazol-5-ylcarbamate

Base Information

• Chemical Name: tert-butyl oxazol-5-ylcarbamate
• CAS No.: 1346809-07-1
• Molecular Formula: C8H12N2O3
• Molecular Weight: 184
• Hs Code.: 2934999090
• Mol file: 1346809-07-1.mol

Synonyms:tert-Butyl oxazol-5-ylcarbamate; tert-Butyloxazol-5-ylcarbamate; Oxazol-5-yl-carbamic acid tert-butyl ester

Chemical Property of tert-butyl oxazol-5-ylcarbamate

Chemical Property:

• Boiling Point: 225.3±13.0 °C(Predicted)
• PKA: 12.45±0.70(Predicted)
• PSA: 67.85000
• Density: 1.192±0.06 g/cm3(Predicted)
• LogP: 2.03520
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-ButylOxazol-5-ylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl oxazol-5-ylcarbamate

There total 1 articles about tert-butyl oxazol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,3-oxazole-5-carboxylic acid (118994-90-4) + tert-butyl alcohol (75-65-0) → tert-butyl oxazol-5-ylcarbamate (1346809-07-1)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; for 18h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.0c00417

Reference yield:

tert-butyl oxazol-5-ylcarbamate (1346809-07-1) → tert-butyl 1H-pyrrolo [2,3-c]pyridine-1-carboxylate (370880-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: toluene / 85 °C / Microwave irradiation; Sealed tube

With sodium hydride; In N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1021/acs.orglett.0c00417

upstream raw materials:

1,3-oxazole-5-carboxylic acid

tert-butyl alcohol

Downstream raw materials:

tert-butyl 1H-pyrrolo [2,3-c]pyridine-1-carboxylate

Refernces