4-Amino-2-ethylpyridine

Base Information

• Chemical Name: 4-Amino-2-ethylpyridine
• CAS No.: 50826-64-7
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• European Community (EC) Number: 866-842-3
• DSSTox Substance ID: DTXSID40475859
• Nikkaji Number: J1.485.159C
• Wikidata: Q82306667
• Mol file: 50826-64-7.mol

Synonyms:4-Amino-2-ethylpyridine;2-ethylpyridin-4-amine;50826-64-7;MFCD12032815;2-ethyl-4-aminopyridine;2-Ethyl-pyridin-4-ylamine;SCHEMBL694797;DTXSID40475859;AKZCAQJRKXGRMH-UHFFFAOYSA-N;AKOS006337837;SB22922;AS-50895;SY026184;CS-0051911;FT-0766664;EN300-109312;P11358

Chemical Property of 4-Amino-2-ethylpyridine

Chemical Property:

• Boiling Point: 128-130 °C(Press: 4-5 Torr)
• PKA: 9.59±0.30(Predicted)
• PSA: 38.91000
• Density: 1.037±0.06 g/cm3(Predicted)
• LogP: 1.80740
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

97% ^*data from raw suppliers

2-Ethylpyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=NC=CC(=C1)N

Technology Process of 4-Amino-2-ethylpyridine

There total 7 articles about 4-Amino-2-ethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-ethyl-4-nitropyridine N-oxide (38594-62-6) → 4-amino-2-ethylpyridine (50826-64-7)

Guidance literature:

With iron; ammonium chloride; In ethanol; for 3h; Reflux;

Reference yield:

(Z)-7-Methoxy-hept-6-en-4-yn-3-one (340006-63-5) → 4-amino-2-ethylpyridine (50826-64-7) + 2-ethyl-4-methoxypyridine (211758-93-9)

Guidance literature:

With ammonia; In methanol; at 160 - 165 ℃; for 14h; under 10084.4 Torr; Title compound not separated from byproducts;

DOI:10.1002/(SICI)1099-1344(199802)41:2<151::AID-JLCR64>3.0.CO;2-R

Reference yield:

methanol (67-56-1) + (Z)-7-Methoxy-hept-6-en-4-yn-3-one (340006-63-5) → 4-amino-2-ethylpyridine (50826-64-7) + 2-ethyl-4-methoxypyridine (211758-93-9)

Guidance literature:

With ammonia; at 160 - 165 ℃; for 14h; under 10084.4 Torr; Title compound not separated from byproducts;

DOI:10.1002/(SICI)1099-1344(199802)41:2<151::AID-JLCR64>3.0.CO;2-R

upstream raw materials:

2-ethyl-4-nitropyridine N-oxide

methanol

(Z)-7-Methoxy-hept-6-en-4-yn-3-one

2-ethylpyridine 1-oxide

Downstream raw materials:

4-chloro-2-ethylpyridine

2-ethyl-4-pyridinecarbonitrile

ethionamide

phenyl (2-ethylpyridin-4-yl)carbamate