Pyridine, 3-chloro-5-(phenylmethoxy)-

Base Information

• Chemical Name: Pyridine, 3-chloro-5-(phenylmethoxy)-
• CAS No.: 251996-81-3
• Molecular Formula: C12H10ClNO
• Molecular Weight: 219.671
• Hs Code.: 2933399090
• Mol file: 251996-81-3.mol

Synonyms:5-chloro-3-benzofurancarboxylic acid ethyl ester;Ethyl 5-chlorobenzofuran-3-carboxylate;5-Chloro-3-benzyloxypyridine;5-chlorobenzofuran-3-carboxylic acid ethyl ester;5-chloro-3-ethoxycarbonylbenzofuran;3-benzyloxy-5-chloropyridine;

Chemical Property of Pyridine, 3-chloro-5-(phenylmethoxy)-

Chemical Property:

• PSA: 22.12000
• LogP: 3.31400

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-5-(phenylmethoxy)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 3-chloro-5-(phenylmethoxy)-

There total 2 articles about Pyridine, 3-chloro-5-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

5-chloropyridin-3-ol (74115-12-1) + benzyl bromide (100-39-0) → 3-(benzyloxy)-5-chloropyridine (251996-81-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1002/anie.200503479

Reference yield: 36.0%

5-chloropyridin-3-ol (74115-12-1) + diethylazodicarboxylate (1972-28-7,218603-74-8) → 3-(benzyloxy)-5-chloropyridine (251996-81-3)

Guidance literature:

With triphenylphosphine; benzyl alcohol; In tetrahydrofuran; diethyl ether;

Reference yield:

3-(benzyloxy)-5-chloropyridine (251996-81-3) + mesitylenesulfonylhydroxylamine (36016-40-7) → 1-amino-3-(benzyloxy)-5-chloropyridin-1-ium 2,4,6-trimethylbenzenesulfonate

Guidance literature:

In dichloromethane; water; at 0 ℃; for 1.08333h; Inert atmosphere;

upstream raw materials:

5-chloropyridin-3-ol

benzyl bromide

diethylazodicarboxylate

Downstream raw materials:

C₁₂H₉ClFNO

C₁₂H₉ClFNO