1-Benzylpyrrolo[2,3-b]pyridine-2,3-dione

Base Information

• Chemical Name: 1-Benzylpyrrolo[2,3-b]pyridine-2,3-dione
• CAS No.: 281192-96-9
• Molecular Formula: C14H10N2O2
• Molecular Weight: 238.246
• DSSTox Substance ID: DTXSID801219333
• Nikkaji Number: J1.284.256B
• Mol file: 281192-96-9.mol

Synonyms:281192-96-9;SCHEMBL2473625;DTXSID801219333;1-(Phenylmethyl)-1H-pyrrolo[2,3-b]pyridine-2,3-dione

Chemical Property of 1-Benzylpyrrolo[2,3-b]pyridine-2,3-dione

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 238.074227566
• Heavy Atom Count: 18
• Complexity: 350

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C3=C(C=CC=N3)C(=O)C2=O

Technology Process of 1-Benzylpyrrolo[2,3-b]pyridine-2,3-dione

There total 2 articles about 1-Benzylpyrrolo[2,3-b]pyridine-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-benzyl-3-bromo-1H-pyrrolo[2,3-b]pyridine (281192-93-6) → 1-benzyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione (281192-96-9) + 1-benzyl-2,3-dibromo-1H-pyrrolo[2,3-b]pyridine + 1-benzyl-3,3-dibromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one

Guidance literature:

With N-Bromosuccinimide; dimethyl sulfoxide; at 60 - 80 ℃;

DOI:10.3987/COM-99-8792

Reference yield: 83.0%

1-benzyl-1H-pyrrolo[2,3-b]-pyridine (152955-68-5) → 1-benzyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione (281192-96-9)

Guidance literature:

With aluminum (III) chloride; silica gel; pyridinium chlorochromate; In 1,2-dichloro-ethane; at 80 ℃; for 1.5h; Inert atmosphere;

DOI:10.1080/00397911.2011.584008

Reference yield: 89.0%

4R-4-hydroxyproline (51-35-4,30724-02-8) + 1-benzyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione (281192-96-9) → 1-benzyl-(1H-pyrrol-1-yl)-1H-pyrrol[2,3-b]pyridin-2(3H)-one

Guidance literature:

dysprosium(III) triflate; In acetonitrile; at 80 ℃; for 0.933333h;

DOI:10.1016/j.tetlet.2007.02.134

upstream raw materials:

1-benzyl-3-bromo-1H-pyrrolo[2,3-b]pyridine

1-benzyl-1H-pyrrolo[2,3-b]-pyridine

Downstream raw materials:

1-benzyl-5'-bromo-7-azaindirubin