281192-93-6

Usage

Uses

Used in Organic Synthesis:
1-BENZYL-3-BROMO-7-AZAINDOLE is used as a building block in organic synthesis for the creation of a variety of biologically active molecules. Its unique structure allows for the development of new compounds with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-BENZYL-3-BROMO-7-AZAINDOLE is employed as a precursor for the synthesis of pharmaceuticals. Its structural features make it a promising candidate for the development of new drugs with improved therapeutic properties.
Used in Drug Discovery:
1-BENZYL-3-BROMO-7-AZAINDOLE serves as a useful tool in drug discovery, particularly for understanding the structure-activity relationships of indole-based compounds. This knowledge can be applied to design and optimize new drugs with enhanced efficacy and selectivity.
Used in Pharmaceutical Industry:
1-BENZYL-3-BROMO-7-AZAINDOLE is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its potential pharmacological properties, such as anti-inflammatory and anti-cancer activities, make it a valuable component in the development of novel therapeutic agents.
Used in Research and Development:
In research and development, 1-BENZYL-3-BROMO-7-AZAINDOLE is utilized to explore its potential pharmacological properties and evaluate its efficacy in treating various diseases. 1-BENZYL-3-BROMO-7-AZAINDOLE provides valuable insights into the development of new drugs and therapeutic strategies.

Upstream product

• 152955-68-5 1-benzyl-1H-pyrrolo[2,3-b]-pyridine 
• 100-39-0 benzyl bromide 
• 74420-15-8 3-bromo-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 

Downstream Products

• 281192-96-9 1-benzyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione 

Relevant academic research and scientific papers

AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS

Provided herein are thiazole carboxamide protein secretin inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

Intramolecular Oxidative Arylations in 7-Azaindoles and Pyrroles: Revamping the Synthesis of Fused N-Heterocycle Tethered Fluorenes

We revealed intramolecular oxidative arylations in 7-azaindoles and pyrroles that, for the first time, provided direct access to 7-azaindole- or pyrrole-fused isoindolines and tetrahydroisoquinolines. In addition, N-benzylation of 7-azaindoles or pyrroles with sterically hindered sec-benzyl alcohols by Mitsunobu reaction followed by intramolecular oxidative arylation allowed access to chiral congeners of fused isoindolines that have little precedence. A new opportunity in the design and synthesis of fluorene-based organic emitters is demonstrated in the preparation of novel fused N-heterocycle tethered fluorenes, including a chiral fluorene architecture.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bc1-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bc1-xL protein.

A facile synthesis of 1-alkyl-7-azaisatins

1-Alkyl-7-azaisatins are synthesized from the reaction of 1-alkyl-7- azaindoles with bromine in dichloromethane and subsequent oxidation with N- bromosuccinimide - dimethyl sulfoxide reagent. 1-Alkyl-7-azaindoles are readily available in high yields from