Imidazo[1,2-a]pyridine-5-carboxaldehyde, 3-nitro-

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-5-carboxaldehyde, 3-nitro-
• CAS No.: 429690-44-8
• Molecular Formula: C8H5N3O3
• Molecular Weight: 0.00000
• Mol file: 429690-44-8.mol

Synonyms:

Chemical Property of Imidazo[1,2-a]pyridine-5-carboxaldehyde, 3-nitro-

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

98% ^*data from raw suppliers

3-Nitro-imidazo[1,2-a]pyridine-5-carbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Imidazo[1,2-a]pyridine-5-carboxaldehyde, 3-nitro-

There total 3 articles about Imidazo[1,2-a]pyridine-5-carboxaldehyde, 3-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

imidazo[1,2-a]pyridine-5-carbaldehyde (372147-50-7) → 3-nitroimidazo[1,2-a]pyridine-5-carbaldehyde (429690-44-8)

Guidance literature:

With nitric acid; In sulfuric acid; at -10 - 20 ℃; for 4h;

DOI:10.3987/com-01-9347

Reference yield:

ethyl 6-aminopicolinate (69142-64-9) → 3-nitroimidazo[1,2-a]pyridine-5-carbaldehyde (429690-44-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / NaHCO₃ / aq. ethanol / 9 h / Heating

2: 79 percent / DIBAL-H / CH₂Cl₂ / 3 h / -70 °C

3: 75 percent / aq. nitric acid / H₂SO₄ / 4 h / -10 - 20 °C

With nitric acid; diisobutylaluminium hydride; sodium hydrogencarbonate; In ethanol; dichloromethane; sulfuric acid;

DOI:10.3987/com-01-9347

Reference yield:

ethyl (imidazo[1,2-a]pyridin-5-yl)carboxylate (177485-39-1) → 3-nitroimidazo[1,2-a]pyridine-5-carbaldehyde (429690-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / DIBAL-H / CH₂Cl₂ / 3 h / -70 °C

2: 75 percent / aq. nitric acid / H₂SO₄ / 4 h / -10 - 20 °C

With nitric acid; diisobutylaluminium hydride; In dichloromethane; sulfuric acid;

DOI:10.3987/com-01-9347

upstream raw materials:

imidazo[1,2-a]pyridine-5-carbaldehyde

ethyl 6-aminopicolinate

ethyl (imidazo[1,2-a]pyridin-5-yl)carboxylate