2'-HYDROXYGENISTEIN

Base Information

• Chemical Name: 2'-HYDROXYGENISTEIN
• CAS No.: 1156-78-1
• Molecular Formula: C15H10 O6
• Molecular Weight: 286.241
• Hs Code.: 2914501900
• Mol file: 1156-78-1.mol

Synonyms:Isoflavone,2',4',5,7-tetrahydroxy- (6CI,7CI,8CI); 2',4',5,7-Tetrahydroxyisoflavone;2'-Hydroxygenistein; 2'-Hydroxyisoprunetin

Chemical Property of 2'-HYDROXYGENISTEIN

Chemical Property:

• Boiling Point: 619.1oC at 760 mmHg
• Flash Point: 240.7oC
• PSA: 111.13000
• Density: 1.654g/cm3
• LogP: 2.28240
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'-Hydroxygenistein 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2''-Hydroxygenistein acts as an α-glucosidase inhibitor which is useful as an antidiabetic and obese agent.

Technology Process of 2'-HYDROXYGENISTEIN

There total 24 articles about 2'-HYDROXYGENISTEIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2',4',5,7-tetrakis(benzyloxy)isoflavone (82458-45-5) → 2',4',5,7-tetrahydroxyisoflavone (1156-78-1)

Guidance literature:

With hydrogenolyse; palladium on activated charcoal; In methanol;

DOI:10.1246/bcsj.58.136

Reference yield: 89.0%

5,7,2',4'-tetramethoxyisoflavone (1100-15-8) → 2',4',5,7-tetrahydroxyisoflavone (1156-78-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -15 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2019.130589

Reference yield: 73.0%

2',4',5,7-tetramethoxymethoxyisoflavone (1344028-49-4) → 2',4',5,7-tetrahydroxyisoflavone (1156-78-1)

Guidance literature:

With hydrogenchloride; water; In methanol; at 50 ℃; for 12h;

DOI:10.1016/j.tet.2011.09.042

upstream raw materials:

5,7,2',4'-tetramethoxyisoflavone

2',4',5,7-tetrakis(benzyloxy)isoflavone

4',6'-bis(benzyloxy)-2'-(methoxymethoxy)acetophenone

(E)-1-(2,4-Bis-benzyloxy-6-hydroxy-phenyl)-3-(2,4-bis-benzyloxy-phenyl)-propenone

Downstream raw materials:

Lupinalbin A

luteone

2',4',5,7-tetraacetoxy-3',5'-bis(3-methyl-2-butenyl)isoflavone

2',4',5,7-tetraacetoxy-5'-(3-methyl-2-butenyl)isoflavone

Refernces

• 1、 Asebi, Nana,Nihei, Ken-ichi. "Total synthesis of apios isoflavones and investigation of their tyrosinase inhibitory activity". . . Retrieved 2019/09/12.
• 2、 Tsukayama, Masao,Oda, Akihiro,Kawamura, Yasuhiko,Nishiuchi, Masaki,Yamashita, Kazuyo. "Facile synthesis of polyhydroxycoumaronochromones with quinones: Synthesis of alkylpolyhydroxy- and alkoxycoumaronochromones from 2′-hydroxyisoflavones". . p. 6163 - 6166. Retrieved 2007/10/03.