methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

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Chemical Name:methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate
CAS No.:1615714-13-0
Molecular Formula:C₁₈H₁₇FN₂O₃
Molecular Weight:328.343
Hs Code.:

Synonyms:methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

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Chemical Property of methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

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Technology Process of methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

There total 6 articles about methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1615714-12-9
1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

: 1615714-13-0
methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

Guidance literature:: 1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine; With triethylamine; In toluene; for 0.166667h; Inert atmosphere;

methanol; carbon monoxide; With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In toluene; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm500571f

Reference yield:

: 1116136-36-7
1H-pyrrolo[3,2-b]pyridine 4-oxide

: 1615714-13-0
methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 2 h / 120 °C / Inert atmosphere

2.1: caesium carbonate / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

2.2: 16 h / 120 °C / Inert atmosphere

3.1: N-iodo-succinimide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

4.2: 4 h / Inert atmosphere

5.1: triethylamine / toluene / 0.17 h / Inert atmosphere

5.2: 16 h / 50 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; caesium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm500571f

Reference yield:

: 1190312-40-3
3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

: 1615714-13-0
methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere

2.1: triethylamine / toluene / 0.17 h / Inert atmosphere

2.2: 16 h / 50 °C / Inert atmosphere

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm500571f