1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

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Chemical Name:1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine
CAS No.:1615714-12-9
Molecular Formula:C₁₆H₁₄FIN₂O
Molecular Weight:396.203
Hs Code.:

Synonyms:1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

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Chemical Property of 1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

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Technology Process of 1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

There total 4 articles about 1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.4%

: 1190312-40-3
3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

: 19415-40-8
2-(chloromethyl)-4-fluoro-1-methoxybenzene

: 1615714-12-9
1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: 3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h; Inert atmosphere;

2-(chloromethyl)-4-fluoro-1-methoxybenzene; In N,N-dimethyl-formamide; mineral oil; for 4h; Inert atmosphere;
DOI:10.1021/jm500571f

Reference yield:

: 1116136-36-7
1H-pyrrolo[3,2-b]pyridine 4-oxide

: 1615714-12-9
1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 2 h / 120 °C / Inert atmosphere

2.1: caesium carbonate / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

2.2: 16 h / 120 °C / Inert atmosphere

3.1: N-iodo-succinimide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

4.2: 4 h / Inert atmosphere

With N-iodo-succinimide; sodium hydride; caesium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm500571f

Reference yield:

: 272-49-1
1H-pyrrolo[3,2-b]pyridine

: 1615714-12-9
1-(5-fluoro-2-methoxybenzyl)-3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 2 h / 120 °C / Inert atmosphere

3.1: caesium carbonate / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

3.2: 16 h / 120 °C / Inert atmosphere

4.1: N-iodo-succinimide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

5.2: 4 h / Inert atmosphere

With N-iodo-succinimide; sodium hydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm500571f