2-Amino-3-formylchromone

Base Information

• Chemical Name: 2-Amino-3-formylchromone
• CAS No.: 61424-76-8
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.17
• Hs Code.: 2922509090
• European Community (EC) Number: 624-966-3
• DSSTox Substance ID: DTXSID50352884
• Nikkaji Number: J1.869.084E
• Wikidata: Q82130291
• ChEMBL ID: CHEMBL87426
• Mol file: 61424-76-8.mol

Synonyms:2-aminochromone-3-carboxaldehyde

Chemical Property of 2-Amino-3-formylchromone

Chemical Property:

• Vapor Pressure: 1.2E-06mmHg at 25°C
• Melting Point: 249oC (dec.)(lit.)
• Boiling Point: 401.2°C at 760 mmHg
• PKA: 1.31±0.20(Predicted)
• Flash Point: 241°C
• PSA: 73.30000
• Density: 1.486g/cm³
• LogP: 1.76890
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 189.042593085
• Heavy Atom Count: 14
• Complexity: 309

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3-formylchromone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)C(=C(O2)N)C=O
• Uses: 2-Amino-3-formylchromone may be used in the preparation of the following:chiral Schiff base ligands (R)/(S)-2-amino-3-(((1-hydroxypropan-2-yl)imino)methyl)-4H-chromen-4-onehydrazone derivatives, required for the synthesis of heterocyclic Schiff′s bases having antimicrobial activityN-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene)amino]phenyl}-3,5-dimethyl-benzofuran-2-carboxamideN-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene)amino]phenyl}-1,4-dihydro-chromono [2,3-b]pyrrole-2-carboxamide6-chloro-3-{[4-(2-thioxo-3,6-dihydro-2H-1,3,4-thiadiazin-5-ylamino)phenylimino] methyl}- 4-oxo-4H -chromene3--(2-amino--4--oxo--4H--chromen--3--yl)methylidene)--6-- ethyl--2H--pyrano[3,2--c]quinolone--2,4,5(3H,6H)-trione

Technology Process of 2-Amino-3-formylchromone

There total 1 articles about 2-Amino-3-formylchromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-oxo-4H-1-benzopyran-3-carbonitrile (50743-17-4) + ethylenediamine (107-15-3,85404-18-8) → 2-amino-3-formylchromone (61424-76-8) + 2-<(2-hydroxybenzoyl)methylene>-1,3,4,5-tetrahydroimidazole (73262-05-2)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1021/jo01298a042

Reference yield: 95.0%

2-amino-3-formylchromone (61424-76-8) + ethyl acetoacetate (141-97-9) + phenylhydrazine (100-63-0) → (Z)-4-((2-amino-4-oxo-4H-chromen-3-yl)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

Guidance literature:

With silica-supported zinc bromide (SiO₂/ZnBr₂); In water; at 60 ℃; for 0.25h; Microwave irradiation; Green chemistry;

DOI:10.1039/c5ra21146h

Reference yield: 90.0%

2-amino-3-formylchromone (61424-76-8) + p-chlorobenzoylacetonitrile (4640-66-8) → 2-(4-chlorophenyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carbonitrile (869637-43-4)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

DOI:10.3987/com-07-11128

upstream raw materials:

4-oxo-4H-1-benzopyran-3-carbonitrile

ethylenediamine

Downstream raw materials:

3-phenyl-3H-chromeno[2,3-d]pyrimidine-2,5-dione

2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carbonitrile

2-amino-4H-1-benzopyran-4-one

4-hydroxy[1]benzopyran-2-one

Refernces