Methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate

Base Information

• Chemical Name: Methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate
• CAS No.: 1095822-17-5
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.16000
• Hs Code.: 2933990090
• Mol file: 1095822-17-5.mol

Synonyms:7H-PYRROLO[2,3-D]PYRIMIDINE-4-CARBOXYLIC ACID,METHYL ESTER;C-8379;

Chemical Property of Methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate

Chemical Property:

• PSA: 67.87000
• LogP: 0.74450

Purity/Quality:

99%, ^*data from raw suppliers

Methyl7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate

There total 3 articles about Methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 4-iodo-7H-pyrrolo[2,3-d]pyrimidine (1100318-96-4) + carbon monoxide (201230-82-2) → methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate (1095822-17-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 100 ℃; under 3750.38 Torr; Inert atmosphere;

Reference yield: 72.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate (1095822-17-5)

Guidance literature:

With dichloro[2,2′ -bis(diphenylphosphino)-1,1′ -binaphthyl]palladium(II); triethylamine; at 100 ℃; for 12h;

Reference yield:

4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate (1095822-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen iodide / 16 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 100 °C / 3750.38 Torr / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen iodide; triethylamine;

upstream raw materials:

methanol

carbon monoxide

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-iodo-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

methyl 7-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate

7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid

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