6-BroMo-1,3-diMethyl-1H-i...

Base Information

• Chemical Name: 6-BroMo-1,3-diMethyl-1H-i...
• CAS No.: 1095539-84-6
• Molecular Formula: C9H9BrN2
• Molecular Weight: 225.088
• Hs Code.: 2933990090
• Mol file: 1095539-84-6.mol

Synonyms:6-Bromo-1,3-dimethyl-1H-indazole;

Chemical Property of 6-BroMo-1,3-diMethyl-1H-i...

Chemical Property:

• Boiling Point: 310.9±22.0 °C(Predicted)
• PKA: 1.38±0.50(Predicted)
• PSA: 17.82000
• Density: 1.53±0.1 g/cm3(Predicted)
• LogP: 2.64420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-1,3-dimethyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-1,3-diMethyl-1H-i...

There total 7 articles about 6-BroMo-1,3-diMethyl-1H-i... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methanesulfonic acid 2-acetyl-5-bromo-phenyl ester (865156-82-7) + methylhydrazine (60-34-4) → 6-bromo-1,3-dimethyl-1H-indazole (1095539-84-6)

Guidance literature:

With ammonium acetate; for 144h; Heating / reflux;

Reference yield: 25.9%

6-bromo-3-methyl-1 H-indazole (7746-27-2) + methyl iodide (74-88-4) → 6-bromo-1,3-dimethyl-1H-indazole (1095539-84-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

6-bromo-3-methyl-1 H-indazole (7746-27-2) → 6-bromo-1,3-dimethyl-1H-indazole (1095539-84-6) + 6-bromo-2,3-dimethyl-1H-indazole (1142189-49-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.416667h; under 760.051 Torr; Microwave irradiation;

upstream raw materials:

methanesulfonic acid 2-acetyl-5-bromo-phenyl ester

methylhydrazine

6-bromo-3-methyl-1 H-indazole

methyl iodide

Downstream raw materials:

2-(1-(4-amino-3-(1,3-dimethyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one