5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one

Base Information

Chemical Name:5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one
CAS No.:945980-21-2
Molecular Formula:C12H11NO2
Molecular Weight:201.22
Hs Code.:2933399090
Mol file:945980-21-2.mol

Synonyms:Reaxys ID: 11103423;5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one;2(1H)-Pyridinone, 5-(4-hydroxyphenyl)-1-Methyl-;5-(4-hydroxyphenyl)-1-Methyl-1,2-dihydropyridin-2-one;4-(1,6-Dihydro-1-methyl-6-oxopyridin-3-yl)phenol, 1,2-Dihydro-5-(4-hydroxyphenyl)-1-methyl-2-oxopyridine

Suppliers and Price of 5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one
100 mg
$ 72.00

SynChem
5-(4-hydroxyphenyl)-1-methylpyridin-2(1H)-one 95+%
500 mg
$ 300.00

Apolloscientific
5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one
100mg
$ 66.00

American Custom Chemicals Corporation
5-(4-HYDROXYPHENYL)-1-METHYLPYRIDIN-2-(1H)-ONE 95.00%
5MG
$ 496.47

Total 6 raw suppliers

Chemical Property of 5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one

Chemical Property:

PSA：42.23000
LogP:1.75790

Purity/Quality:

98% ^*data from raw suppliers

5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one

There total 5 articles about 5-(4-Hydroxyphenyl)-1-methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 945980-20-1
5-(4-methoxyphenyl)-1-methylpyridin-2(1H)-one

: 945980-21-2
C₁₂H₁₁NO₂

Guidance literature:: With hydrogen bromide; acetic acid; for 16h; Heating;
DOI:10.1016/j.bmcl.2007.04.049

Reference yield:

: 766-11-0
5-bromo-2-fluoropyridine

: 945980-21-2
C₁₂H₁₁NO₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / KOH; n-Bu₄NBr / Pd(PPh₃)4 / tetrahydrofuran / 19 h / Heating

2.1: 100 percent / aq. HCl / dioxane / 24 h / Heating

3.1: LiH / dimethylformamide / 1.5 h / 50 °C

3.2: 68 percent / dimethylformamide / 16 h

4.1: 83 percent / HBr; AcOH / 16 h / Heating

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; hydrogen bromide; lithium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1.1: Suzuki cross coupling;
DOI:10.1016/j.bmcl.2007.04.049

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 945980-21-2
C₁₂H₁₁NO₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / KOH; n-Bu₄NBr / Pd(PPh₃)4 / tetrahydrofuran / 19 h / Heating

2.1: 100 percent / aq. HCl / dioxane / 24 h / Heating

3.1: LiH / dimethylformamide / 1.5 h / 50 °C

3.2: 68 percent / dimethylformamide / 16 h

4.1: 83 percent / HBr; AcOH / 16 h / Heating

With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide; hydrogen bromide; lithium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1.1: Suzuki cross coupling;
DOI:10.1016/j.bmcl.2007.04.049