N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE
• CAS No.: 1011-59-2
• Molecular Formula: C11H16ClN.ClH
• Molecular Weight: 234.169
• Mol file: 1011-59-2.mol

Synonyms:3-dimethylamino-1-phenyl-1-propyl chloride hydrochloride;N,N-dimethyl-3-chloro-3-phenylpropylamine hydrochloride;(+/-)3-chloro-N,N-dimethyl-3-phenylpropylamine,hydrochloride;N,N-dimethyl-3-phenyl-3-chloropropylamine hydrochloride;3-chloro-N,N-dimethyl-3-phenylpropylamine hydrochloride;N,N-dimethyl 3-phenyl-3-chloropropylamine hydrochloride;

Chemical Property of N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 3.24000
• LogP: 3.72020
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3-Chloro-3-phenyl-propyl)-dimethyl-aminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE

There total 5 articles about N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-dimethyl-3-hydroxy-3-phenylpropylamine (5554-64-3) → 3-(dimethylamino)-1-phenylpropyl chloride hydrochloride (1011-59-2)

Guidance literature:

N,N-dimethyl-3-hydroxy-3-phenylpropylamine; With hydrogenchloride; In diethyl ether;

With thionyl chloride; Reflux;

DOI:10.1039/d0ra03509b

Reference yield: 94.7%

NSC 12229 (5424-50-0) → 3-(dimethylamino)-1-phenylpropyl chloride hydrochloride (1011-59-2)

Guidance literature:

With thionyl chloride; orthoformic acid triethyl ester; In toluene; at -30 - -20 ℃; for 5h;

Reference yield:

acetophenone (98-86-2) → 3-(dimethylamino)-1-phenylpropyl chloride hydrochloride (1011-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol / 2 h / Reflux

2.1: potassium hydroxide / water

2.2: 1.5 h / 0 - 22 °C

3.1: hydrogenchloride / diethyl ether

3.2: Reflux

With hydrogenchloride; potassium hydroxide; In diethyl ether; ethanol; water;

DOI:10.1039/d0ra03509b

upstream raw materials:

N,N-dimethyl-3-hydroxy-3-phenylpropylamine

NSC 12229

acetophenone

3-(dimethylamino)propiophenone hydrochloride

Downstream raw materials:

[3-(4-Benzyl-piperazin-1-yl)-3-phenyl-propyl]-dimethyl-amine

N,N-dimethyl-γ-[4-(methylthio)phenoxy]benzenepropanamine ethanedioate

N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)-1-propylamine

N,N-dimethyl-3-(2-methyl-phenyloxy)-3-phenyl-propanamine

Refernces

• 1、 Tóth, Katalin,Wenzel, Nicole I.,Chavain, Natascha,Wang, Yulin,Friebolin, Wolfgang,Maes, Louis,Pradines, Bruno,Lanzer, Michael,Yardley, Vanessa,Brun, Reto,Herold-Mende, Christel,Biot, Christophe,Davioud-Charvet, Elisabeth. "Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and mannich bases: Interaction with DNA". experimental part. p. 3214 - 3226. Retrieved 2010/10/19.
• 2、 -. "3-PHENYLOXY-3-PHENYL PROPANAMINES". . . Retrieved 2008/06/13.