4-Cyano-2,3-difluorobenzoic acid

Base Information

• Chemical Name: 4-Cyano-2,3-difluorobenzoic acid
• CAS No.: 1033997-04-4
• Molecular Formula: C8H3F2NO2
• Molecular Weight: 183.114
• Mol file: 1033997-04-4.mol

Synonyms:4-cyano-2,3-difluoro-benzoic acid;

Chemical Property of 4-Cyano-2,3-difluorobenzoic acid

Chemical Property:

• PSA: 61.09000
• LogP: 1.53468

Purity/Quality:

99% ^*data from raw suppliers

4-Cyano-2,3-difluorobenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Cyano-2,3-difluorobenzoic acid

There total 1 articles about 4-Cyano-2,3-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-difluoro-4-methylbenzonitrile (508203-48-3) → 4-cyano-2,3-difluoro-benzoic acid (1033997-04-4)

Guidance literature:

With chromium(VI) oxide; periodic acid; In acetonitrile; at 20 ℃; for 1.25h;

Reference yield: 78.0%

4-cyano-2,3-difluoro-benzoic acid (1033997-04-4) → 2,3-difluoro-4-(hydroxymethyl)benzonitrile

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 44.0%

4-heptafluoroisopropyl-2,6-dimethylaniline (273735-43-6) + 4-cyano-2,3-difluoro-benzoic acid (1033997-04-4) → 4-cyano-2,3-difluoro-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide (1033997-05-5)

Guidance literature:

4-cyano-2,3-difluoro-benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 - 60 ℃; for 2.5h;

4-heptafluoroisopropyl-2,6-dimethylaniline; With pyridine; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

2,3-difluoro-4-methylbenzonitrile

Downstream raw materials:

4-cyano-2,3-difluoro-N-[2,6-dimethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-benzamide

4-cyano-2,3-difluorobenzoyl chloride

N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

3-amino-N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-4-cyano-2-fluorobenzamide

Refernces