N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

Base Information

Chemical Name:N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide
CAS No.:1207976-73-5
Molecular Formula:C₂₄H₉BrClF₁₁N₄O₂
Molecular Weight:709.7
Hs Code.:

Synonyms:N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

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Chemical Property of N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

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Technology Process of N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

There total 7 articles about N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 58757-38-3
6-Chloronicotinoyl chloride

: 1207315-88-5
3-amino-N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-4-cyano-2-fluorobenzamide

: 1207976-73-5
N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

Guidance literature:: With 1,3-dimethyl-2-imidazolidinone; at 130 ℃; for 6h;

Reference yield:

: 1033997-04-4
4-cyano-2,3-difluoro-benzoic acid

: 1207976-73-5
N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: 1,3-dimethyl-2-imidazolidinone / 5 h / 130 °C

3: ammonium carbonate / dimethyl sulfoxide / 5 h / 100 °C

4: 1,3-dimethyl-2-imidazolidinone / 6 h / 130 °C

With 1,3-dimethyl-2-imidazolidinone; oxalyl dichloride; ammonium carbonate; N,N-dimethyl-formamide; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1207315-89-6
N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-4-cyano-2,3-difluorobenzamide

: 1207976-73-5
N-(3-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenylcarbamoyl)-6-cyano-2-fluorophenyl)-6-chloronicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium carbonate / dimethyl sulfoxide / 5 h / 100 °C

2: 1,3-dimethyl-2-imidazolidinone / 6 h / 130 °C

With 1,3-dimethyl-2-imidazolidinone; ammonium carbonate; In dimethyl sulfoxide;