(z)-tert-Butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate

Base Information

• Chemical Name: (z)-tert-Butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate
• CAS No.: 1143571-97-4
• Molecular Formula: C22H35N5O4
• Molecular Weight: 433.551
• Mol file: 1143571-97-4.mol

Synonyms:(Z)-tert-butyl (tert-butoxycarbonylaMino)(4-(4-Methylpiperazin-1-yl)phenylaMino)MethylenecarbaMate

Chemical Property of (z)-tert-Butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate

Chemical Property:

• PSA: 95.50000
• LogP: 4.13290

Purity/Quality:

(Z)-TERT-BUTYL (TERT-BUTOXYCARBONYLAMINO)(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)METHYLENECARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (z)-tert-Butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate

There total 3 articles about (z)-tert-Butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(4-Methyl-piperazino)-anilin (16153-81-4) + (Z)-tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate (152120-54-2,862686-58-6,1143572-00-2) → (Z)-tert-butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate (1143571-97-4)

Guidance literature:

In acetonitrile; at 25 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b00098

Reference yield: 91.0%

N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-54-2,862686-58-6,1143572-00-2) + 3-(4-methylpiperazin-1-yl)aniline (148546-99-0) → (E)-tert-butyl (tert-butoxycarbonylamino)(3-(4-methyl-piperazin-1-yl)-phenylamino)methylenecarbamate (1143571-97-4)

Guidance literature:

In acetonitrile; at 25 ℃; for 20h;

Reference yield:

4-(4-Methyl-piperazino)-anilin (16153-81-4) + N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-54-2,862686-58-6,1143572-00-2) → (Z)-tert-butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate (1143571-97-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 17h;

upstream raw materials:

N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

3-(4-methylpiperazin-1-yl)aniline

4-(4-Methyl-piperazino)-anilin

(Z)-tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)carbamate

Downstream raw materials:

1-(3-(4-methylpiperazin-1-yl)phenyl)guanidine

2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ol

1-(4-(4-methylpiperazin-1-yl)phenyl)guanidine

1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

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