Guanidine, N-[3-(4-Methyl-1-piperazinyl)phenyl]-

Base Information

• Chemical Name: Guanidine, N-[3-(4-Methyl-1-piperazinyl)phenyl]-
• CAS No.: 770671-04-0
• Molecular Formula: C12H19N5
• Molecular Weight: 233.316
• Hs Code.: 2933599090
• Mol file: 770671-04-0.mol

Synonyms:2-[3-(4-methylpiperazin-1-yl)phenyl]guanidine;1-(3-(4-Methylpiperazin-1-yl)phenyl)guanidine;Guanidine, N-[3-(4-Methyl-1-piperazinyl)phenyl]-

Chemical Property of Guanidine, N-[3-(4-Methyl-1-piperazinyl)phenyl]-

Chemical Property:

• PSA: 68.38000
• LogP: 1.61970

Purity/Quality:

99% ^*data from raw suppliers

1-(3-(4-METHYLPIPERAZIN-1-YL)PHENYL)GUANIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Guanidine, N-[3-(4-Methyl-1-piperazinyl)phenyl]-

There total 3 articles about Guanidine, N-[3-(4-Methyl-1-piperazinyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-tert-butyl (tert-butoxycarbonylamino)(3-(4-methyl-piperazin-1-yl)-phenylamino)methylenecarbamate (1143571-97-4) → 1-(3-(4-methylpiperazin-1-yl)phenyl)guanidine (770671-04-0)

Guidance literature:

(E)-tert-butyl (tert-butoxycarbonylamino)(3-(4-methyl-piperazin-1-yl)-phenylamino)methylenecarbamate; With trifluoroacetic acid; In dichloromethane; at 10 - 25 ℃; for 12h;

With sodium hydroxide; In water;

With hydrogenchloride; ammonium hydroxide; more than 3 stages;

Reference yield:

CYANAMID (420-04-2) + 3-(4-methylpiperazin-1-yl)aniline (148546-99-0) → 1-(3-(4-methylpiperazin-1-yl)phenyl)guanidine (770671-04-0)

Guidance literature:

With chloro-trimethyl-silane; Heating;

DOI:10.1016/j.ejmech.2013.08.052

Reference yield:

→ 1-(3-(4-methylpiperazin-1-yl)phenyl)guanidine (770671-04-0)

Guidance literature:

upstream raw materials:

(E)-tert-butyl (tert-butoxycarbonylamino)(3-(4-methyl-piperazin-1-yl)-phenylamino)methylenecarbamate

CYANAMID

3-(4-methylpiperazin-1-yl)aniline

Downstream raw materials:

4-[1-methyl-3-(4-nitro-phenyl)-1H-pyrazol-4-yl]-N-[3-(4-methyl-piperazin-1-yl)phenyl]-pyrimidin-2-amine

6-amino-5-(2,2-diethoxy-ethyl)-2-[3-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-ol